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Articles Published Processes
5/24/2024 8:33:44 AM | Browse: 84 | Download: 379
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Received |
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2023-12-13 09:22 |
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Peer-Review Started |
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2023-12-13 09:22 |
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To Make the First Decision |
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Return for Revision |
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2024-01-15 09:14 |
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Revised |
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2024-01-29 18:13 |
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Second Decision |
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2024-03-28 01:53 |
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Accepted by Journal Editor-in-Chief |
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2024-03-31 07:06 |
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Accepted by Executive Editor-in-Chief |
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2024-04-01 02:51 |
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Articles in Press |
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2024-04-01 02:51 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-05-13 09:18 |
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Publish the Manuscript Online |
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2024-05-24 08:33 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hang Zhang, Ling-Zi Wu, Zhen-Yu Liu and Zi-Bing Jin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82125007 |
| Beijing Natural Science Foundation |
Z200014 |
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| Corresponding Author |
Zi-Bing Jin, MD, PhD, Research Scientist, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing 100730, China. jinzb502@ccmu.edu.cn |
| Key Words |
Cell junction; Cellular differentiation; Extracellular vesicle; Human induced pluripotent stem cells; Transcriptomics; Proteomics |
| Core Tip |
Patient-specific human induced pluripotent stem cell (hiPSC) technology is a valuable tool for disease modeling and the investigation of disease mechanisms, but altered biological properties caused by pathogenic genes may limit hiPSC applications. Through transcriptomics and proteomics, this study revealed cell junction abnormalities and aberrant cellular differentiation potential in hiPSCs with a MERTK mutation. Furthermore, the profiles of hiPSC-derived extracellular vesicles collected for transcriptomic and proteomic analysis indicated their involvement in the changes of biological characteristics occurring in hiPSCs. |
| Publish Date |
2024-05-24 08:33 |
| Citation |
<p>Zhang H, Wu LZ, Liu ZY, Jin ZB. Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential. <i>World J Stem Cells</i> 2024; 16(5): 512-524</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i5/512.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i5.512 |
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