Publication Name	World Journal of Gastroenterology
Manuscript ID	9079
Country	China

Received	2014-01-20 08:25
Peer-Review Started	2014-01-20 13:44
To Make the First Decision	2014-02-28 17:18
Return for Revision	2014-03-07 16:58
Revised	2014-04-03 17:05
Second Decision	2014-05-29 20:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 20:30
Articles in Press	2014-05-29 21:07
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-25 21:53
Typeset the Manuscript	2014-12-08 13:36
Publish the Manuscript Online	2014-12-20 19:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells
Manuscript Source	Unsolicited Manuscript
All Author List
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30770991 National Natural Science Foundation of China 30800511 Esophageal Carcinoma Innovative Research Program of Jiangsu Provincial Hospitals
Corresponding Author	Prof. Ruihua Shi Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. Tel: 86-25-83718836, ext. 6973; Fax: 86-25-83674636; Email: ruihuashi@126.com
Key Words	Esophageal squamous cell carcinoma; Hypoxia-inducible factor-1α; VE-cadherin; RNA interference; Vasculogenic mimicry
Core Tip	Hypoxia inducible factor (HIF) is a key factor to regulate and promote the progression of tumor. In this process, angiogenesis and vasculogenic mimicry may play a important role to help tumors acquire more blood supply. In this paper, we discussed the role of HIF-1α (The α subunit of HIF-1) in the formation of vasculogenic mimicry in Esophageal squamous cell carcinoma(ESCC). Our study showed that HIF-1α may up-regulate the expression of VE-cadherin to accommodate the ability of forming vasculogenic mimicry in ESCC and which may relate to the change of EphA2 and LN5γ2 protien expression. These results may also have implications in the treatment of malignant tumor disease.
Publish Date	2014-12-20 19:42
Citation	Tang NN, Zhu H, Zhang HJ, Zhang WF, Jin HL, Wang L, Wang P, He GJ, Hao B, Shi RH. HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells. World J Gastroenterol 2014; 20(47): 17894-17904
URL	http://www.wjgnet.com/1007-9327/full/v20/i47/17894.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i47.17894

Full Article (PDF)	WJG-20-17894.pdf
Full Article (Word)	WJG-20-17894.doc
Manuscript File	9079-Review.doc
Answering Reviewers	9079-Answering reviewers.pdf
Copyright License Agreement	9079-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9079-Language certificate.PDF
Peer-review Report	9079-Peer reivew(s).pdf
Scientific Misconduct Check	9079-CrossCheck.jpg
Scientific Editor Work List	9079-Scientific editor work list.pdf