Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90849
Country	China

Received	2023-12-15 14:16
Peer-Review Started	2023-12-15 14:16
First Decision by Editorial Office Director	2023-12-22 05:11
Return for Revision	2023-12-22 05:11
Revised	2024-01-11 08:19
Publication Fee Transferred
Second Decision by Editor	2024-03-04 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-03-04 05:34
Articles in Press	2024-03-04 05:34
Edit the Manuscript by Language Editor	2024-03-08 02:23
Typeset the Manuscript	2024-04-23 08:36
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Association of complement components with the risk of colorectal cancer: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Lin Zhu, Lu Zhang and Su-Xia Qi
ORCID	Author(s) ORCID Number Su-Xia Qi http://orcid.org/0009-0001-4729-4179
Funding Agency and Grant Number
Corresponding Author	Su-Xia Qi, MA, N/A, N/A, Department of Gastroenterology, Qingdao Municipal Hospital, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China. qisuxia_0@163.com
Key Words	Complement components; Colorectal cancer; Lymph node metastasis; Systematic review; Meta-analysis
Core Tip	This meta-analysis provides evidence emphasizing that increased levels of specific complement components are associated with high risk of colorectal cancer (CRC). Compared with the healthy control group, protein levels of cluster of differentiation 46 (CD46), CD59, component 1 (C1), and serum levels of C3 were significantly elevated in patients with CRC. Significantly, patients with pronounced expression of CD55 or CD59 manifest a higher incidence of lymph node metastasis. Nevertheless, these findings emphasize the need for methodologically rigorous studies with larger sample sizes to corroborate these preliminary conclusions.
Publish Date	2024-05-09 13:59
Citation	Zhu XL, Zhang L, Qi SX. Association of complement components with the risk of colorectal cancer: A systematic review and meta-analysis. World J Gastrointest Oncol 2024; 16(5): 2168-2180
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/2168.htm
DOI	10.4251/wjgo.v16.i5.2168

Full Article (PDF)	WJGO-16-2168-with-cover.pdf