Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	90849
Country	China

Received	2023-12-15 14:16
Peer-Review Started	2023-12-15 14:16
To Make the First Decision
Return for Revision	2023-12-22 05:11
Revised	2024-01-11 08:19
Second Decision	2024-03-04 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-04 05:34
Articles in Press	2024-03-04 05:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-03-08 02:23
Typeset the Manuscript	2024-04-23 08:36
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Association of complement components with the risk of colorectal cancer: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Lin Zhu, Lu Zhang and Su-Xia Qi
ORCID	Author(s) ORCID Number Su-Xia Qi http://orcid.org/0009-0001-4729-4179
Funding Agency and Grant Number
Corresponding Author	Su-Xia Qi, MA, N/A, N/A, Department of Gastroenterology, Qingdao Municipal Hospital, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China. qisuxia_0@163.com
Key Words	Complement components; Colorectal cancer; Lymph node metastasis; Systematic review; Meta-analysis
Core Tip	This meta-analysis provides evidence emphasizing that increased levels of specific complement components are associated with high risk of colorectal cancer (CRC). Compared with the healthy control group, protein levels of cluster of differentiation 46 (CD46), CD59, component 1 (C1), and serum levels of C3 were significantly elevated in patients with CRC. Significantly, patients with pronounced expression of CD55 or CD59 manifest a higher incidence of lymph node metastasis. Nevertheless, these findings emphasize the need for methodologically rigorous studies with larger sample sizes to corroborate these preliminary conclusions.
Publish Date	2024-05-09 13:59
Citation	Zhu XL, Zhang L, Qi SX. Association of complement components with the risk of colorectal cancer: A systematic review and meta-analysis. World J Gastrointest Oncol 2024; 16(5): 2168-2180
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/2168.htm
DOI	10.4251/wjgo.v16.i5.2168

Full Article (PDF)	WJGO-16-2168-with-cover.pdf
PRISMA 2009 Checklist	90849-PRISMA 2009 Checklist.pdf
Manuscript File	90849_Auto_Edited-YJP_WangTQ.docx
Answering Reviewers	90849-Answering reviewers.pdf
Audio Core Tip	90849-Audio core tip.aac
Biostatistics Review Certificate	90849-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90849-Conflict-of-interest statement.pdf
Copyright License Agreement	90849-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	90849-Language certificate.pdf
Supplementary Material	90849-Supplementary material.pdf
Peer-review Report	90849-Peer-review(s).pdf
Scientific Misconduct Check	90849-Bing-Wang JJ-2.png
Scientific Editor Work List	90849-Scientific editor work list.pdf
CrossCheck Report	90849-CrossCheck report.pdf