Publication Name	World Journal of Hepatology
Manuscript ID	90872
Country	Australia

Received	2023-12-16 03:05
Peer-Review Started	2023-12-16 03:05
To Make the First Decision
Return for Revision	2024-01-18 07:23
Revised	2024-01-30 09:27
Second Decision	2024-03-19 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-19 08:59
Articles in Press	2024-03-19 08:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-16 01:18
Publish the Manuscript Online	2024-04-24 08:35

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Systematic Reviews
Article Title	Relative carcinogenicity of tacrolimus vs mycophenolate after solid organ transplantation and its implications for liver transplant care
Manuscript Source	Unsolicited Manuscript
All Author List	Dorothy Liu, Mark M Youssef, Josephine A Grace and Marie Sinclair
ORCID	Author(s) ORCID Number Dorothy Liu http://orcid.org/0000-0002-7802-2803 Josephine A Grace http://orcid.org/0000-0002-8435-4740 Marie Sinclair http://orcid.org/0000-0003-0657-3115
Funding Agency and Grant Number
Corresponding Author	Dorothy Liu, BMed, FRACP, MD, Doctor, Doctor, Department of Gastroenterology, Austin Health, 145 Studley Road, Heidelberg, Melbourne 3084, Victoria, Australia. dorothy.liu2@austin.org.au
Key Words	Immunosuppression; Solid organ transplantation; Liver transplantation; Carcinogenicity; Tacrolimus; Mycophenolate
Core Tip	Cumulative immunosuppression exposure is an important risk factor for the development of post-transplant malignancy. There is emerging evidence on the differential carcinogenic risk profile of individual immunosuppressive drugs, independent of the net immunosuppression effect. This review demonstrates that the evidence on the relative carcinogenicity of tacrolimus and mycophenolic acid, the two agents most commonly used as maintenance monotherapy in liver transplant patients, remains unclear. Further studies are required to determine the clinical relevance of previous experimental findings to enable physicians to tailor immunosuppression regimens to minimize individual malignancy risk in solid organ transplantation.
Publish Date	2024-04-24 08:35
Citation	Liu D, Youssef MM, Grace JA, Sinclair M. Relative carcinogenicity of tacrolimus vs mycophenolate after solid organ transplantation and its implications for liver transplant care. World J Hepatol 2024; 16(4): 650-660
URL	https://www.wjgnet.com/1948-5182/full/v16/i4/650.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i4.650

Full Article (PDF)	WJH-16-650-with-cover.pdf
PRISMA 2009 Checklist	90872-PRISMA 2009 checklist.pdf
Manuscript File	90872_Auto_Edited-YJP.docx
Answering Reviewers	90872-Answering reviewers.pdf
Audio Core Tip	90872-Audio core tip.mp3
Biostatistics Review Certificate	90872-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90872-Conflict-of-interest statement.pdf
Copyright License Agreement	90872-Copyright license agreement.pdf
Peer-review Report	90872-Peer-review(s).pdf
Scientific Misconduct Check	90872-Bing-Chen YL-2.png
Scientific Editor Work List	90872-Scientific editor work list.pdf
CrossCheck Report	90872-CrossCheck report.pdf