| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Chemistry, Medicinal |
| Manuscript Type |
Basic Study |
| Article Title |
Bidirectional effects of the tryptophan metabolite indole-3-acetaldehyde on colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ze Dai, Kai-Li Deng, Xiao-Mei Wang, Dong-Xue Yang, Chun-Lan Tang and Yu-Ping Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Provincial Natural Science Foundation of China |
No. LTGD23C040008 |
| Zhejiang Provincial Natural Science Foundation of China |
No. LBY23H200006 |
| Zhejiang Provincial Natural Science Foundation of China |
No. LQ22H030004 |
|
| Corresponding Author |
Yu-Ping Zhou, PhD, Doctor, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, No. 247 Renmin Road, Jiangbei District, Ningbo 315020, Zhejiang Province, China. fyzhouyuping@nbu.edu.cn |
| Key Words |
Indole-3-acetaldehyde; Colorectal cancer; Tryptophan metabolism; Apoptosis; Epithelial–mesenchymal transition |
| Core Tip |
In this study, we investigated the effect of an indole derivative of the gut microbiota, indole-3-acetaldehyde (IAAD), on colorectal cancer (CRC). The growth of tumors in a syngeneic mouse model, as well as the proliferation, apoptosis, invasion, and epithelial mesenchymal transition of the HCT116 and DLD-1 cell lines, were observed. At a low concentration (12.5 μmol/L), IAAD can inhibit cell proliferation and induce cell apoptosis, but at high concentrations (≥ 25 μmol/L), it has a dual role of cytotoxicity and promotion of tumor cell invasiveness. Our results contribute to existing knowledge regarding the complex role of the gut microbiota in the occurrence and development of CRC. |
| Publish Date |
2024-06-15 02:49 |
| Citation |
Dai Z, Deng KL, Wang XM, Yang DX, Tang CL, Zhou YP. Bidirectional effects of the tryptophan metabolite indole-3-acetaldehyde on colorectal cancer. World J Gastrointest Oncol 2024; 16(6): 2697-2715 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i6/2697.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i6.2697 |
