Publication Name	World Journal of Gastroenterology
Manuscript ID	90913
Country	China

Received	2023-12-17 09:36
Peer-Review Started	2023-12-17 09:36
To Make the First Decision
Return for Revision	2023-12-25 04:14
Revised	2024-01-08 17:27
Second Decision	2024-03-04 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-04 05:09
Articles in Press	2024-03-04 05:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-18 04:09
Publish the Manuscript Online	2024-03-21 11:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Chao Hu, Xiang-Chun Ding, Hui-Juan Liu, Wan-Long Ma, Xue-Yan Feng and Li-Na Ma
ORCID	Author(s) ORCID Number Yan-Chao Hu http://orcid.org/0000-0002-5570-5222 Xiang-Chun Ding http://orcid.org/0000-0003-0283-9419 Hui-Juan Liu http://orcid.org/0009-0001-2741-9659 Wan-Long Ma http://orcid.org/0009-0007-3658-1571 Xue-Yan Feng http://orcid.org/0009-0000-5773-0862 Li-Na Ma http://orcid.org/0000-0002-6244-7997
Funding Agency and Grant Number	Funding Agency Grant Number The Health System Research Project of Ningxia Hui Autonomous Region of China No. 2022-NWKY-061
Corresponding Author	Xiang-Chun Ding, PhD, Doctor, Doctor, Department of Infectious Disease, General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 13619511768@163.com
Key Words	Hepatitis B cirrhosis; N1115 ready-to-eat lactobacillus; Inflammation; Liver function; Lachnospiraceae incertae sedis; Probiotic
Core Tip	Intestinal microbial imbalance and metabolic dysfunction may accelerate the process of liver cirrhosis. We explored the role of probiotic intervention in patients with hepatitis B cirrhosis in this study. After an intervention with the N1115 ready-to-eat Lactobacillus supplement, we found the following significant changes: an increase in gut microbial diversity, structural changes in the microbiota favoring the growth of probiotic microbes, improvements in liver function, and decreases in inflammatory factor levels. We conclude that supplementation with the N1115 ready-to-eat Lactobacillus product may be a beneficial intervention in patients with cirrhosis.
Publish Date	2024-03-21 11:37
Citation	Hu YC, Ding XC, Liu HJ, Ma WL, Feng XY, Ma LN. Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis. World J Gastroenterol 2024; 30(11): 1556-1571
URL	https://www.wjgnet.com/1007-9327/full/v30/i11/1556.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i11.1556

Full Article (PDF)	WJG-30-1556-with-cover.pdf
CONSORT 2010 Statement	90913-CONSORT 2010 statement.pdf
Manuscript File	90913_Auto_Edited-YJP.docx
Answering Reviewers	90913-Answering reviewers.pdf
Audio Core Tip	90913-Audio core tip.mp3
Biostatistics Review Certificate	90913-Biostatistics statement.pdf
Clinical Trial Registration Statement	90913-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	90913-Conflict-of-interest statement.pdf
Copyright License Agreement	90913-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90913-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	90913-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	90913-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90913-Language certificate.pdf
Peer-review Report	90913-Peer-review(s).pdf
Scientific Misconduct Check	90913-Bing-Qu XL-2.jpg
Scientific Editor Work List	90913-Scientific editor work list.pdf
CrossCheck Report	90913-CrossCheck report.pdf