ISSN |
1948-9358 (online) |
Open Access |
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Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Dermatology |
Manuscript Type |
Basic Study |
Article Title |
X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Ming-Wei Du, Xin-Lin Zhu, Dong-Xing Zhang, Xian-Zhen Chen, Li-Hua Yang, Jin-Zhou Xiao, Wen-Jie Fang, Xiao-Chun Xue, Wei-Hua Pan, Wan-Qing Liao and Tao Yang |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Shanghai Science and Technology Innovation Project:One Belt One Road International Joint Laboratory of Medical Mycology |
21410750500 |
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Corresponding Author |
Tao Yang, PhD, Associate Professor, Institute of Cardiovascular Disease, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Pudong New Area, Shanghai 200120, China. yangtao@shutcm.edu.cn |
Key Words |
Diabetes mellitus; Diabetic foot ulcers; NF-E2-related factor-2/HO-1 signaling pathway; Andrographolide |
Core Tip |
Diabetic foot ulcer (DFU) is a severe complication caused by diabetes mellitus. The healing process and time of skin wounds in diabetic mice are visibly improved by the application of X-Paste (XP). The analysis conducted on XP unveiled its 21 main components, with Andrographolide (Andro) displaying a notable binding ability with NF-E2-related factor-2 (Nrf2) by high-performance liquid chromatography. Moreover, the addition of Andro at the cellular level effectively alleviated high glucose (HG)-induced proliferation, migration, vascular injury, and inhibition of inflammatory products in human umbilical vein endothelial cells (HUVECs). Mechanistically, the Nrf2/HO-1 signaling pathway is activated by Andro, leading to the relief of HG-induced damage to HUVECs. |
Publish Date |
2024-06-11 14:35 |
Citation |
<p>Du MW, Zhu XL, Zhang DX, Chen XZ, Yang LH, Xiao JZ, Fang WJ, Xue XC, Pan WH, Liao WQ, Yang T. X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway. <i>World J Diabetes</i> 2024; 15(6): 1299-1316</p> |
URL |
https://www.wjgnet.com/1948-9358/full/v15/i6/1299.htm |
DOI |
https://dx.doi.org/10.4239/wjd.v15.i6.1299 |