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6/11/2024 2:35:36 PM | Browse: 54 | Download: 225
Publication Name World Journal of Diabetes
Manuscript ID 90914
Country China
Received
2023-12-17 12:58
Peer-Review Started
2023-12-17 12:58
To Make the First Decision
Return for Revision
2024-01-24 05:50
Revised
2024-01-31 04:39
Second Decision
2024-03-18 07:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2024-03-25 05:37
Articles in Press
2024-03-25 05:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-05-17 01:55
Publish the Manuscript Online
2024-06-11 14:35
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Dermatology
Manuscript Type Basic Study
Article Title X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway
Manuscript Source Unsolicited Manuscript
All Author List Ming-Wei Du, Xin-Lin Zhu, Dong-Xing Zhang, Xian-Zhen Chen, Li-Hua Yang, Jin-Zhou Xiao, Wen-Jie Fang, Xiao-Chun Xue, Wei-Hua Pan, Wan-Qing Liao and Tao Yang
ORCID
Author(s) ORCID Number
Wei-Hua Pan http://orcid.org/0000-0001-7381-5188
Tao Yang http://orcid.org/0009-0008-9121-4376
Funding Agency and Grant Number
Funding Agency Grant Number
Shanghai Science and Technology Innovation Project:One Belt One Road International Joint Laboratory of Medical Mycology 21410750500
Corresponding Author Tao Yang, PhD, Associate Professor, Institute of Cardiovascular Disease, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Pudong New Area, Shanghai 200120, China. yangtao@shutcm.edu.cn
Key Words Diabetes mellitus; Diabetic foot ulcers; NF-E2-related factor-2/HO-1 signaling pathway; Andrographolide
Core Tip Diabetic foot ulcer (DFU) is a severe complication caused by diabetes mellitus. The healing process and time of skin wounds in diabetic mice are visibly improved by the application of X-Paste (XP). The analysis conducted on XP unveiled its 21 main components, with Andrographolide (Andro) displaying a notable binding ability with NF-E2-related factor-2 (Nrf2) by high-performance liquid chromatography. Moreover, the addition of Andro at the cellular level effectively alleviated high glucose (HG)-induced proliferation, migration, vascular injury, and inhibition of inflammatory products in human umbilical vein endothelial cells (HUVECs). Mechanistically, the Nrf2/HO-1 signaling pathway is activated by Andro, leading to the relief of HG-induced damage to HUVECs.
Publish Date 2024-06-11 14:35
Citation <p>Du MW, Zhu XL, Zhang DX, Chen XZ, Yang LH, Xiao JZ, Fang WJ, Xue XC, Pan WH, Liao WQ, Yang T. X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway. <i>World J Diabetes</i> 2024; 15(6): 1299-1316</p>
URL https://www.wjgnet.com/1948-9358/full/v15/i6/1299.htm
DOI https://dx.doi.org/10.4239/wjd.v15.i6.1299
Full Article (PDF) WJD-15-1299-with-cover.pdf
The ARRIVE Guidelines 90914-The-ARRIVE-Guidelines.pdf
Manuscript File 90914_Auto_Edited-YJP-2024-04-29.docx
Answering Reviewers 90914-answering-reviewers.pdf
Audio Core Tip 90914-audio.mp3
Biostatistics Review Certificate 90914-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 90914-conflict-of-interest-statement.pdf
Copyright License Agreement 90914-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 90914-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 90914-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate 90914-non-native-speakers.pdf
Supplementary Material 90914-supplementary-material.pdf
Peer-review Report 90914-peer-reviews.pdf
Journal Editor-in-Chief Review Report 90914-journal-editor-in-chief.pdf
Scientific Misconduct Check 90914-scientific-misconduct-check.png
Scientific Editor Work List 90914-scientific-editor-work-list.pdf
CrossCheck Report 90914-crosscheck-report.pdf