Publication Name	World Journal of Clinical Oncology
Manuscript ID	9093
Country	United States

Received	2014-01-21 09:02
Peer-Review Started	2014-01-21 21:46
To Make the First Decision	2014-02-13 16:00
Return for Revision	2014-02-20 20:50
Revised	2014-03-11 11:26
Second Decision	2014-06-20 11:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-20 12:09
Articles in Press	2014-06-20 13:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-21 16:15
Publish the Manuscript Online	2014-08-01 15:17

ISSN	2218-4333 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer
Manuscript Source	Invited Manuscript
All Author List	Meng Zhao and Bhuvaneswari Ramaswamy
Funding Agency and Grant Number
Corresponding Author	Bhuvaneswari Ramaswamy, MD, MRCP, Assistant Professor, Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, The Ohio State University’s Wexner Medical Center, Columbus, OH 43210, United States. bhuvaneswari.ramaswamy@osumc.edu
Key Words	Endocrine therapy; Endocrine resistance; Breast cancer; Therapeutic advances; Targeted therapy
Core Tip	Endocrine therapy is the important systemic therapy for hormone receptor positive breast cancer. However, treatment resistance is common. Multiple mechanisms responsible for endocrine resistance have been identified over the past decade. New treatment combinations targeting estrogen receptor and growth factor receptor signaling which block the crosstalk between these pathways are effective in preclinical models and clinical studies. In this review, we summarize the complex genomic and epigenetic regulatory pathways involved in endocrine resistance, in particular focusing on the clinical trials utilizing novel strategies to overcome therapeutic resistance.
Publish Date	2014-08-01 15:17
Citation	Zhao M, Ramaswamy B. Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer. World J Clin Oncol 2014; 5(3): 248-262
URL	http://www.wjgnet.com/2218-4333/full/v5/i3/248.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i3.248

Full Article (PDF)	WJCO-5-248.pdf
Full Article (Word)	WJCO-5-248.doc
Manuscript File	9093-Review.doc
Answering Reviewers	9093-Answering reviewers.pdf
Copyright License Agreement	9093-Copyright assignment.pdf
Peer-review Report	9093-Peer review(s).pdf
Scientific Misconduct Check	9093-CrossCheck.pdf
Scientific Editor Work List	9093-Scientific editor work list.pdf