| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
N6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Zhang, Fang Zhou, Ming-Yu Zhang, Li-Na Feng, Jia-Lun Guan, Ruo-Nan Dong, Yu-Jie Huang, Su-Hong Xia, Jia-Zhi Liao and Kai Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Sub-Project of the National Key Research and Development Program |
2021YFC2600263 |
|
| Corresponding Author |
Kai Zhao, MD, PhD, Doctor, Doctor, Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. zhaokai0227@126.com |
| Key Words |
N6-methyladenosine methylation; Tumor microenvironment; Epstein-Barr virus; Gastric cancer; Insulin-like growth factor binding protein 1 |
| Core Tip |
In this work, we found that N6-methyladenosine methylation regulators activated the expression of immune cells and inflammatory factors in Epstein-Barr virus-associated gastric cancer (EBVaGC), which could remodel the tumor microenvironment. EBVaGC is classified as an immune-inflamed phenotype and referred to as a “hot” tumor. Insulin-like growth factor binding protein 1 affected the proliferation, migration, and apoptosis of EBVaGC. Thus, our study provided a theoretical basis for future research on the pathogenesis and therapeutic targets of EBVaGC. |
| Publish Date |
2024-06-15 02:49 |
| Citation |
Zhang Y, Zhou F, Zhang MY, Feng LN, Guan JL, Dong RN, Huang YJ, Xia SH, Liao JZ, Zhao K. N6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer. World J Gastrointest Oncol 2024; 16(6): 2555-2570 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i6/2555.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i6.2555 |
