Publication Name	World Journal of Gastroenterology
Manuscript ID	9102
Country	Italy

Received	2014-01-21 09:42
Peer-Review Started	2014-01-21 20:49
First Decision by Editorial Office Director
Return for Revision	2014-03-31 10:05
Revised	2014-04-30 00:00
Publication Fee Transferred
Second Decision by Editor	2014-05-26 21:25
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-26 21:46
Articles in Press	2014-05-26 22:04
Edit the Manuscript by Language Editor	2014-07-02 02:29
Typeset the Manuscript	2014-09-12 14:50
Publish the Manuscript Online	2014-10-01 20:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn’s disease, cause or epiphenomenon?
Manuscript Source	Unsolicited Manuscript
All Author List	Elisa Liverani, Eleonora Scaioli, Carla Cardamone, Paola Dal Monte and Andrea Belluzzi
Funding Agency and Grant Number
Corresponding Author	Andrea Belluzzi, MD, Gastroenterology Division, Department of Medical and Surgical Sciences, Sant’Orsola-Malpighi University Hospital, via Massarenti 9, 40138 Bologna, Italy. andrea.belluzzi@aosp.bo.it
Key Words	Mycobacterium avium paratuberculosis; Crohn’s disease; Inflammatory bowel disease; Johne’s disease; Mycobacterial protein tyrosine phosphatase
Core Tip	The etiology of inflammatory bowel disease (IBD) is unknown. Some analogies between Crohn’s disease (CD) and Johne’s disease, a granulomatous chronic enteritis of cattle and sheep caused by Mycobacterium avium subspecies paratuberculosis (MAP) have been identified. Several studies have tried to clarify if MAP has a role in the etiology of CD. However, the involvement of MAP in CD is still debatable. The present article provides a literature review of the evidence in favor and against the “MAP-hypothesis”, the methods commonly adopted to detect MAP and the role of antimycobacterial therapy in treating IBD patients. In particular, new mechanistic findings seem to encourage the CD-MAP relationship.
Publish Date	2014-10-01 20:25
Citation	Liverani E, Scaioli E, Cardamone C, Dal Monte P, Belluzzi A. Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn’s disease, cause or epiphenomenon? World J Gastroenterol 2014; 20(36): 13060-13070
URL	http://www.wjgnet.com/1007-9327/full/v20/i36/13060.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i36.13060

Full Article (PDF)	WJG-20-13060.pdf
Full Article (Word)	WJG-20-13060.doc
Manuscript File	9102-Review.docx
Answering Reviewers	9102-Answering reviewers.PDF
Copyright License Agreement	9102-Copyright assignment.PDF
Peer-review Report	9102-Peer review.pdf
Scientific Misconduct Check	9102-CrossCheck.jpg
Scientific Editor Work List	9102-Scientific editor work list.pdf