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Articles Published Processes
10/1/2014 8:25:00 PM | Browse: 920 | Download: 770
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Received |
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2014-01-21 09:42 |
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Peer-Review Started |
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2014-01-21 20:49 |
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To Make the First Decision |
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2014-03-27 21:16 |
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Return for Revision |
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2014-03-31 10:05 |
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Revised |
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2014-04-30 00:00 |
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Second Decision |
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2014-05-26 21:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-05-26 21:46 |
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Articles in Press |
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2014-05-26 22:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-07-02 02:29 |
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Typeset the Manuscript |
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2014-09-12 14:50 |
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Publish the Manuscript Online |
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2014-10-01 20:25 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Review |
Article Title |
Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn’s disease, cause or epiphenomenon?
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Elisa Liverani, Eleonora Scaioli, Carla Cardamone, Paola Dal Monte and Andrea Belluzzi |
Funding Agency and Grant Number |
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Corresponding Author |
Andrea Belluzzi, MD, Gastroenterology Division, Department of Medical and Surgical Sciences, Sant’Orsola-Malpighi University Hospital, via Massarenti 9, 40138 Bologna, Italy. andrea.belluzzi@aosp.bo.it |
Key Words |
Mycobacterium avium paratuberculosis; Crohn’s disease; Inflammatory bowel disease; Johne’s disease; Mycobacterial protein tyrosine phosphatase |
Core Tip |
The etiology of inflammatory bowel disease (IBD) is unknown. Some analogies between Crohn’s disease (CD) and Johne’s disease, a granulomatous chronic enteritis of cattle and sheep caused by Mycobacterium avium subspecies paratuberculosis (MAP) have been identified. Several studies have tried to clarify if MAP has a role in the etiology of CD. However, the involvement of MAP in CD is still debatable. The present article provides a literature review of the evidence in favor and against the “MAP-hypothesis”, the methods commonly adopted to detect MAP and the role of antimycobacterial therapy in treating IBD patients. In particular, new mechanistic findings seem to encourage the CD-MAP relationship. |
Publish Date |
2014-10-01 20:25 |
Citation |
Liverani E, Scaioli E, Cardamone C, Dal Monte P, Belluzzi A. Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn’s disease, cause or epiphenomenon? World J Gastroenterol 2014; 20(36): 13060-13070 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i36/13060.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i36.13060 |
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