Publication Name	World Journal of Gastroenterology
Manuscript ID	91036
Country	China

Received	2023-12-21 02:21
Peer-Review Started	2023-12-21 02:21
First Decision by Editorial Office Director	2024-01-16 08:14
Return for Revision	2024-01-16 08:14
Revised	2024-01-30 15:31
Publication Fee Transferred
Second Decision by Editor	2024-03-21 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-03-21 03:27
Articles in Press	2024-03-21 03:27
Edit the Manuscript by Language Editor	2024-03-19 14:09
Typeset the Manuscript	2024-04-15 06:39
Publish the Manuscript Online	2024-04-19 08:45

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Sen Li, Qian-Jun Ren, Can-Hao Xie, Yang Cui, Li-Tao Xu, Yi-Dan Wang, Su Li, Xing-Qiu Liang, Bin Wen, Ming-Kun Liang and Xiao-Fang Zhao
ORCID	Author(s) ORCID Number Xing-Qiu Liang http://orcid.org/0000-0003-3378-1336 Ming-Kun Liang http://orcid.org/0000-0002-3854-6434 Xiao-Fang Zhao http://orcid.org/0000-0003-4697-9157
Funding Agency and Grant Number	Funding Agency Grant Number Guangxi Natural Science Foundation Program 2020GXNSFAA297160 Guangxi Natural Science Foundation Program 2018GXNSFBA050050 Guipai Xinglin Youth Talent Project of Guangxi University of Chinese Medicine 2022C042
Corresponding Author	Xiao-Fang Zhao, MA, Chief Doctor, Doctor, Doctor, Department of Science and Technology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning 541100, Guangxi Zhuang Autonomous Region, China. 37940097@qq.com
Key Words	Hepatic stellate cells; Autophagy; Ferroptosis; Molecular docking; Taurine
Core Tip	We have previously demonstrated that treatment of taurine could alleviate liver fibrosis by inhibiting hepatic stellate cell (HSC) activation and inhibiting activated HSC proliferation. Considering the important role of autophagy and ferroptosis in the process of liver fibrosis pathology, we used molecular biology tests and bioinformatic methods to identify the effect of taurine on autophagy and ferroptosis in HSCs in vitro. This study demonstrated for the first time that taurine could inhibit autophagy in HSCs to inhibit their activation while triggering ferroptosis and ferritinophagy to eliminate activated HSCs. Taurine has a direct targeting effect on nuclear receptor coactivator 4, exhibiting the best average binding affinity of -23.95 kcal/mol.
Publish Date	2024-04-19 08:45
Citation	Li S, Ren QJ, Xie CH, Cui Y, Xu LT, Wang YD, Li S, Liang XQ, Wen B, Liang MK, Zhao XF. Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis. World J Gastroenterol 2024; 30 (15): 2143-2154
URL	https://www.wjgnet.com/1007-9327/full/v30/i15/2143.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i15.2143

Full Article (PDF)	WJG-30-2143-with-cover.pdf