| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sen Li, Qian-Jun Ren, Can-Hao Xie, Yang Cui, Li-Tao Xu, Yi-Dan Wang, Su Li, Xing-Qiu Liang, Bin Wen, Ming-Kun Liang and Xiao-Fang Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangxi Natural Science Foundation Program |
2020GXNSFAA297160 |
| Guangxi Natural Science Foundation Program |
2018GXNSFBA050050 |
| Guipai Xinglin Youth Talent Project of Guangxi University of Chinese Medicine |
2022C042 |
|
| Corresponding Author |
Xiao-Fang Zhao, MA, Chief Doctor, Doctor, Doctor, Department of Science and Technology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, No. 10 Huadong Road, Nanning 541100, Guangxi Zhuang Autonomous Region, China. 37940097@qq.com |
| Key Words |
Hepatic stellate cells; Autophagy; Ferroptosis; Molecular docking; Taurine |
| Core Tip |
We have previously demonstrated that treatment of taurine could alleviate liver fibrosis by inhibiting hepatic stellate cell (HSC) activation and inhibiting activated HSC proliferation. Considering the important role of autophagy and ferroptosis in the process of liver fibrosis pathology, we used molecular biology tests and bioinformatic methods to identify the effect of taurine on autophagy and ferroptosis in HSCs in vitro. This study demonstrated for the first time that taurine could inhibit autophagy in HSCs to inhibit their activation while triggering ferroptosis and ferritinophagy to eliminate activated HSCs. Taurine has a direct targeting effect on nuclear receptor coactivator 4, exhibiting the best average binding affinity of -23.95 kcal/mol. |
| Publish Date |
2024-04-19 08:45 |
| Citation |
Li S, Ren QJ, Xie CH, Cui Y, Xu LT, Wang YD, Li S, Liang XQ, Wen B, Liang MK, Zhao XF. Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis. World J Gastroenterol 2024; 30 (15): 2143-2154 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i15/2143.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i15.2143 |
