Publication Name	World Journal of Hepatology
Manuscript ID	91044
Country	China

Received	2023-12-20 15:39
Peer-Review Started	2023-12-20 15:39
To Make the First Decision
Return for Revision	2024-01-05 23:40
Revised	2024-01-10 15:56
Second Decision	2024-01-18 02:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-01-18 06:26
Articles in Press	2024-01-18 06:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-06 07:15
Publish the Manuscript Online	2024-02-27 11:58

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Precision targeting in hepatocellular carcinoma: Exploring ligand-receptor mediated nanotherapy
Manuscript Source	Invited Manuscript
All Author List	Xia-Qing Zhou, Ya-Ping Li and Shuang-Suo Dang
ORCID	Author(s) ORCID Number Xia-Qing Zhou http://orcid.org/0009-0009-7562-8832 Ya-Ping Li http://orcid.org/0000-0002-0900-5559 Shuang-Suo Dang http://orcid.org/0000-0002-8451-1072
Funding Agency and Grant Number	Funding Agency Grant Number Xi'an Jiaotong University Medical "Basic-Clinical" Integration Innovation Project YXJLRH2022067 Shaanxi Postdoctoral Research Program “Orlistat-loaded Nanoparticles as A Targeted Therapeutical Strategy for The Enhanced Treatment of Liver Cancer” 2023BSHYDZZ09
Corresponding Author	Shuang-Suo Dang, PhD, Professor, Department of Infectious Diseases, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xincheng District, Xi'an 710004, Shaanxi Province, China. dangshuangsuo123@xjtu.edu.cn
Key Words	Targeting; Hepatocellular carcinoma; Receptor; Nanomedicine; Chemotherapy
Core Tip	This review explores the innovative field of nanoparticle-mediated targeted drug delivery in hepatocellular carcinoma (HCC), focusing on the critical role of various overexpressed cellular receptors in improving the therapeutic specificity and efficacy of nanomedicines. It comprehensively analyzes recent advances in the development of receptor-targeted nanoparticles, revealing the complex mechanisms behind receptor-mediated drug delivery at the nanoscale. This exploration not only emphasizes the potential of nano-therapies to transform the treatment of HCC, but also provides valuable insights for future research and clinical applications.
Publish Date	2024-02-27 11:58
Citation	Zhou XQ, Li YP, Dang SS. Precision targeting in hepatocellular carcinoma: Exploring ligand-receptor mediated nanotherapy. World J Hepatol 2024; 16(2): 164-176
URL	https://www.wjgnet.com/1948-5182/full/v16/i2/164.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i2.164

Full Article (PDF)	WJH-16-164-with-cover.pdf
Full Article (Word)	WJH-16-164.docx
Manuscript File	91044_Auto_Edited-YJP.docx
Answering Reviewers	91044-Answering reviewers.pdf
Audio Core Tip	91044-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	91044-Conflict-of-interest statement.pdf
Copyright License Agreement	91044-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91044-Grant application form(s).pdf
Peer-review Report	91044-Peer-review(s).pdf
Scientific Editor Work List	91044-Scientific editor work list.pdf
CrossCheck Report	91044-CrossCheck report.pdf
CrossCheck Report	91044-CrossCheck.png