Publication Name	World Journal of Gastroenterology
Manuscript ID	91102
Country	Italy

Received	2023-12-21 16:49
Peer-Review Started	2023-12-21 16:49
First Decision by Editorial Office Director	2024-01-13 08:21
Return for Revision	2024-01-13 08:21
Revised	2024-01-15 21:06
Publication Fee Transferred
Second Decision by Editor	2024-02-08 04:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-02-08 07:31
Articles in Press	2024-02-08 07:31
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-26 05:54
Publish the Manuscript Online	2024-03-06 06:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity?
Manuscript Source	Invited Manuscript
All Author List	Antonietta Gerarda Gravina, Iacopo Panarese, Maria Consiglia Trotta, Michele D'Amico, Raffaele Pellegrino, Franca Ferraraccio, Marilena Galdiero, Roberto Alfano, Paolo Grieco and Alessandro Federico
ORCID	Author(s) ORCID Number Antonietta Gerarda Gravina http://orcid.org/0000-0001-8049-0115 Iacopo Panarese http://orcid.org/0000-0002-7292-5219 Maria Consiglia Trotta http://orcid.org/0000-0001-9813-5955 Michele D'Amico http://orcid.org/0000-0002-6899-0595 Raffaele Pellegrino http://orcid.org/0000-0001-5074-230X Paolo Grieco http://orcid.org/0000-0002-6854-8123 Alessandro Federico http://orcid.org/0000-0002-0885-0793
Funding Agency and Grant Number
Corresponding Author	Raffaele Pellegrino, MD, N/A, N/A, Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. de Crecchio, Naples 80138, Italy. raffaele.pellegrino@unicampania.it
Key Words	Melanocortin 3 receptor; Melanocortin 5 receptor; Ulcerative colitis; Crohn's disease; Inflammatory bowel disease
Core Tip	This study sought to examine the expression levels of Melanocortin 3 and 5 receptors (MC3R and MC5R) in the colons of individuals diagnosed with Crohn's disease and ulcerative colitis. Analysis of tissue samples obtained from both inflamed and non-inflamed sections of the colon revealed a notable increase in the expression of both receptors within inflamed regions compared to non-inflamed areas, with the extent of expression suggesting a potential association with the severity of disease activity. These findings imply that MC3R and MC5R may serve as potential targets for pharmacological interventions in the context of inflammatory bowel diseases.
Publish Date	2024-03-06 06:10
Citation	Gravina AG, Panarese I, Trotta MC, D'Amico M, Pellegrino R, Ferraraccio F, Galdiero M, Alfano R, Grieco P, Federico A. Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients: A matter of disease activity? World J Gastroenterol 2024; 30(9): 1132-1142
URL	https://www.wjgnet.com/1007-9327/full/v30/i9/1132.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i9.1132

Full Article (PDF)	WJG-30-1132-with-cover.pdf
CONSORT 2010 Statement	91102-CONSORT 2010 statement.pdf
Manuscript File	91102_Auto_Edited-JLW.docx
Answering Reviewers	91102-Answering reviewers.pdf
Audio Core Tip	91102-Audio core tip.mp3
Biostatistics Review Certificate	91102-Biostatistics statement.pdf
Clinical Trial Registration Statement	91102-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	91102-Conflict-of-interest statement.pdf
Copyright License Agreement	91102-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	91102-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	91102-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	91102-Language certificate.pdf
Peer-review Report	91102-Peer-review(s).pdf
Scientific Misconduct Check	91102-Bing-Lin C-2.png
Scientific Editor Work List	91102-Scientific editor work list.pdf
CrossCheck Report	91102-CrossCheck.png
CrossCheck Report	91102-CrossCheck report.pdf