Publication Name	World Journal of Gastroenterology
Manuscript ID	9113
Country	United States

Received	2014-01-21 11:40
Peer-Review Started	2014-01-22 15:41
First Decision by Editorial Office Director
Return for Revision	2014-03-05 21:17
Revised	2014-03-26 04:30
Publication Fee Transferred
Second Decision by Editor	2014-05-05 09:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-05 10:03
Articles in Press	2014-05-23 09:39
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-29 16:29
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Proton pump inhibitor responsive esophageal eosinophilia, a distinct disease entity?
Manuscript Source	Invited Manuscript
All Author List	William Munday and Xuchen Zhang
Funding Agency and Grant Number
Corresponding Author	Xuchen Zhang, MD, PhD, Department of Pathology, VA Connecticut Health System and Yale University School of Medicine, 950 Campbell Ave. West Haven, CT 06516, United States. xuchen.zhang@yale.edu
Key Words	Gastroesophageal reflux disease; Eosinophilic esophagitis; Proton pump inhibitor responsive esophageal eosinophilia; Proton pump inhibitor
Core Tip	The concept of pump inhibitor responsive esophageal eosinophilia (PPI-REE) is relatively new. The underlying mechanism(s) of PPI-REE pathogenesis and therapeutic effect of the PPI are still unknown. It is currently still unclear if PPI-REE is a subtype of gastroesophageal reflux disease (GERD), an eosinophilic esophagitis (EoE) phenotype, or a distinct entity. The aim of this manuscript is to review the mechanistic data of the proposed immune modulation/anti-inflammatory role of PPI at the esophageal mucosa, and the existence of PPI-REE as a distinct disease entity from GERD and EoE.
Publish Date	2014-08-18 16:49
Citation	Munday W, Zhang X. Proton pump inhibitor responsive esophageal eosinophilia, a distinct disease entity? World J Gastroenterol 2014; 20(30): 10419-10424
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10419.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10419

Full Article (PDF)	WJG-20-10419.pdf
Full Article (Word)	WJG-20-10419.doc
Manuscript File	9113-Review.docx
Answering Reviewers	9113-Answering reviewers.pdf
Copyright License Agreement	9113-Copyright assignment.pdf
Peer-review Report	9113-Peer review.pdf
Scientific Editor Work List	9113-Scientific editor work list.pdf