| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Edoardo Agosti, Marco Zeppieri, Mattia Ghidoni, Tamara Ius, Alessandro Tel, Marco Maria Fontanella and Pier Paolo Panciani |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Marco Zeppieri, MD, PhD, Doctor, Doctor, Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it |
| Key Words |
Glioma stem cells; Chemoresistance; Radioresistance; Molecular pathways; Targeted therapies; Systematic review |
| Core Tip |
The challenge of treating gliomas persists despite advancements in chemotherapy and radiotherapy, with glioma stem cells (GSCs) contributing to resistance and tumor heterogeneity. This systematic literature review, covering 66 studies, underscores the intricate role of GSCs in therapeutic resistance, particularly highlighting their involvement in DNA repair mechanisms and dynamic cellular state transitions. Targeted therapies face challenges due to GSCs’ high plasticity, and the review emphasizes the need for precision treatments that account for GSC population heterogeneity and the tumor microenvironment’s dynamic nature. Versatile therapeutic agents, including RNA inhibitor/short hairpin RNA, inhibitors (e.g., LY294002, NVP-BEZ235), and monoclonal antibodies (e.g., cetuximab), demonstrate efficacy in overcoming GSC-mediated resistance. Notably, the most common effect on the chemo- and radiotherapy response is a reduction in temozolomide resistance, highlighting the potential for improved outcomes by disrupting GSC-mediated resistance mechanisms in glioblastoma patients. |
| Publish Date |
2024-05-24 08:33 |
| Citation |
<p>Agosti E, Zeppieri M, Ghidoni M, Ius T, Tel A, Fontanella MM, Panciani PP. Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments. <i>World J Stem Cells</i> 2024; 16(5): 604-614</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i5/604.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i5.604 |
