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Articles Published Processes
6/11/2024 2:35:35 PM | Browse: 103 | Download: 578
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Received |
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2023-12-24 12:59 |
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Peer-Review Started |
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2023-12-24 12:59 |
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First Decision by Editorial Office Director |
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2024-04-04 08:52 |
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Return for Revision |
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2024-04-04 08:52 |
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Revised |
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2024-04-04 13:43 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-04-16 09:24 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-04-23 08:39 |
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Articles in Press |
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2024-04-23 08:39 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-05-23 05:01 |
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Publish the Manuscript Online |
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2024-06-11 14:35 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Minireviews |
| Article Title |
Metformin-associated lactic acidosis: A mini review of pathophysiology, diagnosis and management in critically ill patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kay Choong See |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kay Choong See, FCCP, FRCP, MBBS, MRCP, Adjunct Associate Professor, Department of Medicine, National University Hospital, Level 10, NUHS Tower Block, 1E Kent Ridge Road, Singapore 119228, Singapore. kaychoongsee@nus.edu.sg |
| Key Words |
Acid-base equilibrium; Biguanides; Oxidative phosphorylation; Pyruvic acid; Renal replacement therapy |
| Core Tip |
Metformin-associated lactic acidosis (MALA) in critically ill patients may be suspected in a patient who has received metformin and who has a high anion gap metabolic acidosis, and confirmed when lactate exceeds 5 mmol/L. Risk factors include those that reduce renal elimination of metformin and excessive alcohol consumption. Treatment of MALA involves immediate cessation of metformin, supportive management, treating other concurrent causes of lactic acidosis like sepsis, and treating any coexisting diabetic ketoacidosis. Severe MALA requires extracorporeal removal of metformin with either intermittent hemodialysis or continuous kidney replacement therapy. |
| Publish Date |
2024-06-11 14:35 |
| Citation |
See KC. Metformin-associated lactic acidosis: A mini review of pathophysiology, diagnosis and management in critically ill patients. World J Diabetes 2024; 15(6): 1178-1186 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i6/1178.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i6.1178 |
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