| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yang-Zhou Jiang, Lan-Yue Hu, Mao-Shan Chen, Xiao-Jie Wang, Cheng-Ning Tan, Pei-Pei Xue, Teng Yu, Xiao-Yan He, Li-Xin Xiang, Yan-Ni Xiao, Xiao-Liang Li, Qian Ran, Zhong-Jun Li and Li Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| General Program of National Natural Science Foundation of China |
81770197 |
| Scientific and Technological Research Major Program of Chongqing Municipal Education Commission |
KJZD-M202312802 |
| Chongqing Natural Science Foundation of China |
CSTB2022NSCQ-MSX0190, CSTB2022NSCQ-MSX0176 |
| Chongqing Natural Science Foundation of China |
cstc2020jcyj-msxmX0051 |
| Xinqiao Young Postdoc Talent Incubation Program |
2022YQB098 |
|
| Corresponding Author |
Zhong-Jun Li, MD, PhD, Professor, Laboratory of Radiation Biology, Department of Blood Transfusion, Laboratory Medicine Center, The Second Affiliated Hospital, Third Military Medical University, Chongqing 400037, China. johnneyusc@gmail.com |
| Key Words |
Ankyrin repeat domain containing 26; GATA binding protein 2; Thrombocytopenia 2; Transcriptional regulation; Myeloid-derived cell lines |
| Core Tip |
The 5’-untranslated region mutation of ankyrin repeat domain containing 26 (ANKRD26) plays an important role in the pathology of thrombocytopenia 2 (THC2). Considering the predisposition of THC2 patients to myeloid malignancies, further revealing the molecular mechanism of ANKRD26 transcription is warranted. Although Runt related transcription factor 1 and friend leukemia integration 1 have been shown to negatively regulate ANKRD26 expression, no known positive regulators have been reported. Here, we first revealed that GATA binding protein 2 mediates high ANKRD26 expression by binding to its promoter region. We discovered that high ANKRD26 expression was always associated with favorable overall survival. Our study provides insights into the regulatory network of ANKRD26 and the pathological process of THC2. |
| Publish Date |
2024-05-24 08:33 |
| Citation |
<p>Jiang YZ, Hu LY, Chen MS, Wang XJ, Tan CN, Xue PP, Yu T, He XY, Xiang LX, Xiao YN, Li XL, Ran Q, Li ZJ, Chen L. GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines. <i>World J Stem Cells</i> 2024; 16(5): 538-550</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i5/538.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i5.538 |
