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6/11/2024 2:35:35 PM | Browse: 180 | Download: 1070
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Received |
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2023-12-26 02:59 |
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Peer-Review Started |
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2023-12-26 02:59 |
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First Decision by Editorial Office Director |
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2024-02-09 05:21 |
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Return for Revision |
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2024-02-09 05:21 |
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Revised |
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2024-02-22 12:11 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-03-25 05:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-04-01 05:29 |
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Articles in Press |
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2024-04-01 05:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-05-26 11:06 |
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Publish the Manuscript Online |
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2024-06-11 14:35 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Jun Wu, Shu-Yan Zhang, Lin Mu, Zhi-Guo Dong and Yin-Jian Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Project of China |
No. 2019YFC1711605 |
| National Natural Science Foundation of China |
No. 81904257 |
| Medical Innovation Research Project of Science and Technology Commission of Shanghai Municipality |
No. 21Y11923100 |
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| Corresponding Author |
Yin-Jian Zhang, MMed, Chief Physician, Department of Ophthalmology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725 Wanping South Road, Xuhui district, Shanghai 200032, China. zhangyinj@126.com |
| Key Words |
Diabetic retinopathy; HIF-1α/BNIP3/NIX axis; Mitophagy; Heyingwuzi formulation; Traditional Chinese medicine |
| Core Tip |
Our study demonstrates the protective effects and action mechanisms of the Heyingwuzi formulation against diabetic retinopathy (DR) in vivo and in vitro. Here, we developed a new treatment formulation for DR based on traditional Chinese medicine and revealed its action mechanism involving the promotion of mitophagy via regulation of the hypoxia-inducible factor-1α/BCL2-interacting protein 3 (BNIP3)/BNIP3-like (BNIP3L, also known as NIX) axis. |
| Publish Date |
2024-06-11 14:35 |
| Citation |
Wu JJ, Zhang SY, Mu L, Dong ZG, Zhang YJ. Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis. World J Diabetes 2024; 15(6): 1317-1339 |
| URL |
https://www.wjgnet.com/1948-9358/full/v15/i6/1317.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v15.i6.1317 |
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