Publication Name	World Journal of Diabetes
Manuscript ID	91260
Country	China

Received	2023-12-26 02:59
Peer-Review Started	2023-12-26 02:59
To Make the First Decision
Return for Revision	2024-02-09 05:21
Revised	2024-02-22 12:11
Second Decision	2024-03-25 05:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-01 05:29
Articles in Press	2024-04-01 05:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-26 11:06
Publish the Manuscript Online	2024-06-11 14:35

ISSN	1948-9358 (online)
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Jun Wu, Shu-Yan Zhang, Lin Mu, Zhi-Guo Dong and Yin-Jian Zhang
ORCID	Author(s) ORCID Number Jia-Jun Wu http://orcid.org/0000-0002-5257-2022 Shu-Yan Zhang http://orcid.org/0000-0002-4835-0777 Lin Mu http://orcid.org/0000-0002-9639-6972 Zhi-Guo Dong http://orcid.org/0000-0001-8695-8532 Yin-Jian Zhang http://orcid.org/0000-0002-4694-5208
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Project of China No. 2019YFC1711605 National Natural Science Foundation of China No. 81904257 Medical Innovation Research Project of Science and Technology Commission of Shanghai Municipality No. 21Y11923100
Corresponding Author	Yin-Jian Zhang, MMed, Chief Physician, Department of Ophthalmology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725 Wanping South Road, Xuhui district, Shanghai 200032, China. zhangyinj@126.com
Key Words	Diabetic retinopathy; HIF-1α/BNIP3/NIX axis; Mitophagy; Heyingwuzi formulation; Traditional Chinese medicine
Core Tip	Our study demonstrates the protective effects and action mechanisms of the Heyingwuzi formulation against diabetic retinopathy (DR) in vivo and in vitro. Here, we developed a new treatment formulation for DR based on traditional Chinese medicine and revealed its action mechanism involving the promotion of mitophagy via regulation of the hypoxia-inducible factor-1α/BCL2-interacting protein 3 (BNIP3)/BNIP3-like (BNIP3L, also known as NIX) axis.
Publish Date	2024-06-11 14:35
Citation	<p>Wu JJ, Zhang SY, Mu L, Dong ZG, Zhang YJ. Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis. <i>World J Diabetes</i> 2024; 15(6): 1317-1339</p>
URL	https://www.wjgnet.com/1948-9358/full/v15/i6/1317.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i6.1317

Full Article (PDF)	WJD-15-1317-with-cover.pdf
The ARRIVE Guidelines	91260-The-ARRIVE-Guidelines.pdf
Manuscript File	91260_Auto_Edited-YJP.docx
Answering Reviewers	91260-answering-reviewers.pdf
Audio Core Tip	91260-audio.mp3
Biostatistics Review Certificate	91260-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	91260-conflict-of-interest-statement.pdf
Copyright License Agreement	91260-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91260-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	91260-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	91260-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	91260-non-native-speakers.pdf
Supplementary Material	91260-supplementary-material.zip
Peer-review Report	91260-peer-reviews.pdf
Journal Editor-in-Chief Review Report	91260-journal-editor-in-chief.pdf
Scientific Misconduct Check	91260-scientific-misconduct-check.png
Scientific Editor Work List	91260-scientific-editor-work-list.pdf
CrossCheck Report	91260-crosscheck-report.pdf