Publication Name	World Journal of Gastroenterology
Manuscript ID	91308
Country	Argentina

Received	2023-12-27 01:06
Peer-Review Started	2023-12-27 01:06
To Make the First Decision
Return for Revision	2024-01-27 05:50
Revised	2024-02-19 17:11
Second Decision	2024-03-25 03:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-25 04:54
Articles in Press	2024-03-25 04:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-03 02:59
Publish the Manuscript Online	2024-04-12 16:45

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Omics-based biomarkers as useful tools in metabolic dysfunction-associated steatotic liver disease clinical practice: How far are we?
Manuscript Source	Invited Manuscript
All Author List	Julieta Trinks, María F Mascardi, Adrián Gadano and Sebastián Marciano
ORCID	Author(s) ORCID Number Julieta Trinks http://orcid.org/0000-0003-4781-8005 Adrián Gadano http://orcid.org/0000-0002-3590-2472 Sebastián Marciano http://orcid.org/0000-0002-7983-1450
Funding Agency and Grant Number	Funding Agency Grant Number PIP-CONICET 2021-2023 grant 11220200100875CO PICT-2020-Serie A-00788 “Florencio Fiorini Foundation” grants
Corresponding Author	Julieta Trinks, MD, PhD, Associate Research Scientist, Full Professor, Research Scientist, N/A, Instituto de Medicina Traslacional e Ingeniería Biomédica - Consejo Nacional de Investigaciones Científicas y Técnicas - Instituto Universitario del Hospital Italiano - Hospital Italiano de Buenos Aires, Potosí 4240, Ciudad Autónoma de Buenos Aires C1199ACL, Argentina. julieta.trinks@hospitalitaliano.org.ar
Key Words	Metabolic dysfunction-associated steatotic liver disease; Non-alcoholic steatohepatitis; Biomarker; Risk stratification; Omics
Core Tip	Identifying patients with metabolic dysfunction-associated steatotic liver disease (MASLD) at higher risk for adverse outcomes is still a crucial clinical challenge. Novel and non-invasive screening, monitoring, and risk stratification methods are urgently needed. With this aim, omics technologies have revolutionized the process of MASLD biomarker discovery. Although many omics-based biomarkers were identified over the past decades, their translation into clinically useful tests that can guide management decisions has proven more difficult than expected. This review presents an overview of this area’s current state, the conceivable opportunities and challenges of omics-based laboratory diagnostics, and a roadmap for improving MASLD biomarker research.
Publish Date	2024-04-12 16:45
Citation	Trinks J, Mascardi MF, Gadano A, Marciano S. Omics-based biomarkers as useful tools in metabolic dysfunction-associated steatotic liver disease clinical practice: How far are we? World J Gastroenterol 2024; 30(14): 1982-1989
URL	https://www.wjgnet.com/1007-9327/full/v30/i14/1982.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i14.1982

Full Article (PDF)	WJG-30-1982-with-cover.pdf
Manuscript File	91308_Auto_Edited-YJP.docx
Answering Reviewers	91308-Answering reviewers.pdf
Audio Core Tip	91308-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91308-Conflict-of-interest statement.pdf
Copyright License Agreement	91308-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91308-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	91308-Language certificate.pdf
Supplementary Material	91308-Supplementary material.pdf
Peer-review Report	91308-Peer-review(s).pdf
Scientific Misconduct Check	91308-Bing-Wang JJ-2.png
Scientific Editor Work List	91308-Scientific editor work list.pdf