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Articles Published Processes
5/24/2024 8:33:43 AM | Browse: 84 | Download: 425
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Received |
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2023-12-30 22:22 |
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Peer-Review Started |
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2023-12-30 22:22 |
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To Make the First Decision |
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Return for Revision |
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2024-01-17 09:15 |
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Revised |
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2024-01-29 15:11 |
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Second Decision |
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2024-03-18 02:33 |
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Accepted by Journal Editor-in-Chief |
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2024-03-24 06:13 |
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Accepted by Executive Editor-in-Chief |
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2024-04-01 02:38 |
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Articles in Press |
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2024-04-01 02:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2024-03-14 04:17 |
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Typeset the Manuscript |
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2024-05-13 09:18 |
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Publish the Manuscript Online |
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2024-05-24 08:33 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Developmental Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amani Yehya, Joseph Azar, Mohamad Al-Fares, Helene Boeuf, Wassim Abou-Kheir, Dana Zeineddine and Ola Hadadeh |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Council for Scientific Research in Lebanon |
CNRS-L |
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| Corresponding Author |
Ola Hadadeh, PhD, Associate Research Scientist, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Bliss Street-Hamra, Beirut 1107-2020, Lebanon. hadadeh.ola@gmail.com |
| Key Words |
Mouse embryonic stem cells; Self-renewal; Apoptosis; Cardiac differentiation; B-cell lymphoma 2; PIM-2; Metallothionein-1 |
| Core Tip |
Embryonic stem cells (ESCs) exhibit unique characteristics of self-renewal and pluripotency, allowing for their spontaneous differentiation into multiple cell lineages. Apoptotic signaling presents one of the crucial networks that influence embryonic development. In this study, the upregulation of anti-apoptotic genes B-cell lymphoma 2, Pim-2, and metallothionein-1 in mouse ESCs altered cardiac differentiation. This alteration was evidenced by a decreased size of embryoid bodies, a reduced number of beating cardiomyocytes, and an attenuated expression of cardiac markers. The study emphasizes the critical role of apoptosis in cardiac differentiation, providing insights into the regulatory impact of apoptosis on early differentiation pathways. |
| Publish Date |
2024-05-24 08:33 |
| Citation |
<p>Yehya A, Azar J, Al-Fares M, Boeuf H, Abou-Kheir W, Zeineddine D, Hadadeh O. Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells. <i>World J Stem Cells</i> 2024; 16(5): 551-559</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v16/i5/551.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v16.i5.551 |
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