Publication Name	World Journal of Clinical Oncology
Manuscript ID	91347
Country	Russia

Received	2023-12-27 12:05
Peer-Review Started	2023-12-27 12:05
To Make the First Decision
Return for Revision	2024-01-17 02:43
Revised	2024-02-12 18:39
Second Decision	2024-03-28 01:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-28 05:58
Articles in Press	2024-03-28 05:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-09 00:33
Publish the Manuscript Online	2024-05-21 07:25

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance
Manuscript Source	Invited Manuscript
All Author List	Marina A Senchukova, Evgeniy A Kalinin and Nadezhda N Volchenko
ORCID	Author(s) ORCID Number Marina A Senchukova http://orcid.org/0000-0001-8371-740X Evgeniy A Kalinin http://orcid.org/0000-0001-5329-3589
Funding Agency and Grant Number
Corresponding Author	Marina A Senchukova, MD, PhD, Professor, Department of Oncology, Orenburg State Medical University, Sovetskaya Street 6, Orenburg 460000, Russia. masenchukova@yandex.com
Key Words	Lung cancer; Lung squamous cell carcinoma; Tumor microvessels; Tumor stroma; Regional lymph node metastases; Disease recurrence; Disease prognosis
Core Tip	In this retrospective study, we examined the morphology of different types of tumor microvessels, tumor parenchyma, and tumor stroma and their associations with the risk of regional metastasis and disease recurrence in lung squamous cell carcinoma (LUSC) patients. Independent predictors of LUSC metastases in regional lymph nodes were the central location of the tumor (P < 0.00001), the presence of retraction clefts (P = 0.003), capillaries in the solid component of the tumor (P = 0.023) and fragmentation of the solid component of the tumor (P = 0.009), while independent predictors of LUSC recurrence were tumor grade 3 (P = 0.001), N2 stage (P = 0.016), the presence of loose fine fibrous connective tissue in the tumor stroma (P < 0.00001), fragmentation of the tumor solid component (P = 0.0001) and the absence of tumor spread through the alveolar air spaces (P = 0.0083). These findings may help improve the diagnosis and treatment of LUSC.
Publish Date	2024-05-21 07:25
Citation	<p>Senchukova MA, Kalinin EA, Volchenko NN. Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance. <i>World J Clin Oncol</i> 2024; 15(5): 614-634</p>
URL	https://www.wjgnet.com/2218-4333/full/v15/i5/614.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i5.614

Full Article (PDF)	WJCO-15-614-with-cover.pdf
STROBE Statement	91347-STROBE statement.pdf
Manuscript File	91347_Auto_Edited-YJP.docx
Answering Reviewers	91347-Answering reviewers.pdf
Audio Core Tip	91347-Audio core tip.m4a
Biostatistics Review Certificate	91347-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91347-Conflict-of-interest statement.pdf
Copyright License Agreement	91347-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	91347-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	91347-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	91347-Language certificate.pdf
Supplementary Material	91347-Supplementary material.pdf
Peer-review Report	91347-Peer-review(s).pdf
Scientific Misconduct Check	91347-Bing-Li L-2.png
Scientific Editor Work List	91347-Scientific editor work list.pdf
CrossCheck Report	91347-CrossCheck.png
CrossCheck Report	91347-CrossCheck report.pdf