Publication Name	World Journal of Clinical Oncology
Manuscript ID	91364
Country	China

Received	2023-12-27 16:50
Peer-Review Started	2023-12-27 16:50
To Make the First Decision
Return for Revision	2024-01-15 13:28
Revised	2024-01-29 08:15
Second Decision	2024-03-07 03:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-07 07:45
Articles in Press	2024-03-07 07:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-31 11:49
Publish the Manuscript Online	2024-04-22 09:51

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
Manuscript Source	Invited Manuscript
All Author List	De-Yi Geng, Qing-Shan Chen, Wan-Xian Chen, Lin-Sa Zhou, Xiao-Sha Han, Qi-Hu Xie, Geng-Hong Guo, Xue-Fen Chen, Jia-Sheng Chen and Xiao-Ping Zhong
ORCID	Author(s) ORCID Number Jia-Sheng Chen http://orcid.org/0000-0003-2416-4248 Xiao-Ping Zhong http://orcid.org/0000-0002-0601-031X
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82002068 National Natural Science Foundation of China 82272281 Natural Science Foundation of Guangdong Province 2021A1515010949
Corresponding Author	Xiao-Ping Zhong, Doctor, Professor, Department of Plastic and Burns Surgery, The Second Affiliated Hospital of Shantou University Medical College, Dongxia North Road, Shantou 515000, Guangdong Province, China. zhongxiaoping@stu.edu.cn
Key Words	Alternative splicing; Carcinoma, hepatocellular; Metastasic; Liver neoplasms; Prognosis
Core Tip	Metastatic liver cancer refers to tumors formed outside the liver that metastasize to the liver and colonize it. Abnormal alternative splicing is a molecular characteristic unique to almost all tumor types. Most tumors exhibit a wide range of splicing abnormalities compared to the surrounding healthy tissues. This review is the first to provide a detailed summary of the normal splicing process and alterations that occur during metastatic liver cancer by examining splicing factor changes, abnormal splicing, and the contribution of hypoxia to cellular changes.
Publish Date	2024-04-22 09:51
Citation	Geng DY, Chen QS, Chen WX, Zhou LS, Han XS, Xie QH, Guo GH, Chen XF, Chen JS, Zhong XP. Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer. World J Clin Oncol 2024; 15(4): 531-539
URL	https://www.wjgnet.com/2218-4333/full/v15/i4/531.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i4.531

Full Article (PDF)	WJCO-15-531-with-cover.pdf
Manuscript File	91364_Auto_Edited-YJP.docx
Answering Reviewers	91364-Answering reviewers.pdf
Audio Core Tip	91364-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91364-Conflict-of-interest statement.pdf
Copyright License Agreement	91364-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91364-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	91364-Language certificate.pdf
Peer-review Report	91364-Peer-review(s).pdf
Scientific Editor Work List	91364-Scientific editor work list.pdf
CrossCheck Report	91364-CrossCheck report.pdf