| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Innovation in pathogenesis and management of aortic aneurysm
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Maryam Barkhordarian, Hadrian Hoang-Vu Tran, Aiswarya Menon, Sai Priyanka Pulipaka, Izage Kianifar Aguilar, Axel Fuertes, Shraboni Dey, Angel Ann Chacko, Tanni Sethi, Ayrton Bangolo and Simcha Weissman |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Maryam Barkhordarian, MD, Doctor, Doctor, Department of Internal Medicine, Palisades Medical Center, 7600 River Road, North Bergen, NJ 07047, United States. marybarkhordar@gmail.com |
| Key Words |
Aortic aneurysm; Abdominal aneurysm; Thoracic aneurysm; Immunotherapy; Surgical management; Pathophysiology; Inflammation and molecular pathways |
| Core Tip |
This manuscript explores diverse pathophysiologic pathways (inflammation, atherosclerosis and immune system), varied treatment methods (pharmacological, radiation and surgical), and associated factors like inflammatory markers [transforming growth factor-β, interleukin (IL)-1β, tumor necrosis factor-, matrix metalloproteinase-2, IL-6, IL-8]. Genetic disorders linked to aortic aneurysms (AA) include Marfan syndrome, Ehler-Danlos syndrome, Loeys-Dietz syndrome, Cantu syndrome, and JAK-2 mutation. Approaches such as Low laser irradiation, photobiomodulation, UV-B irradiation may impact AA prevention and shrinkage. Medications like Canakinumab, Paricalcitol, peroxisome proliferator–activated receptor-γ agonist and mesenchymal stem cell transplantation are currently under investigation. Additionally, Different minimally invasive, endovascular surgical methods are highlighted. |
| Publish Date |
2024-06-19 10:24 |
| Citation |
Barkhordarian M, Tran HHV, Menon A, Pulipaka SP, Aguilar IK, Fuertes A, Dey S, Chacko AA, Sethi T, Bangolo A, Weissman S. Innovation in pathogenesis and management of aortic aneurysm. World J Exp Med 2024; 14(2): 91408 |
| URL |
https://www.wjgnet.com/2220-315x/full/v14/i2/91408.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v14.i2.91408 |
