| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Innovation in pathogenesis and management of aortic aneurysm
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Maryam Barkhordarian, Hadrian Hoang-Vu Tran, Aiswarya Menon, Sai Priyanka Pulipaka, Izage Kianifar Aguilar, Axel Fuertes, Shraboni Dey, Angel Ann Chacko, Tanni Sethi, Ayrton Bangolo and Simcha Weissman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Maryam Barkhordarian, MD, Doctor, Doctor, Department of Internal Medicine, Palisades Medical Center, 7600 River Road, North Bergen, NJ 07047, United States. marybarkhordar@gmail.com |
| Key Words |
Aortic aneurysm; Abdominal aneurysm; Thoracic aneurysm; Immunotherapy; Surgical management; Pathophysiology; Inflammation and molecular pathways |
| Core Tip |
This manuscript explores diverse pathophysiologic pathways (inflammation, atherosclerosis and immune system), varied treatment methods (pharmacological, radiation and surgical), and associated factors like inflammatory markers [transforming growth factor-β, interleukin (IL)-1β, tumor necrosis factor-, matrix metalloproteinase-2, IL-6, IL-8]. Genetic disorders linked to aortic aneurysms (AA) include Marfan syndrome, Ehler-Danlos syndrome, Loeys-Dietz syndrome, Cantu syndrome, and JAK-2 mutation. Approaches such as Low laser irradiation, photobiomodulation, UV-B irradiation may impact AA prevention and shrinkage. Medications like Canakinumab, Paricalcitol, peroxisome proliferator–activated receptor-γ agonist and mesenchymal stem cell transplantation are currently under investigation. Additionally, Different minimally invasive, endovascular surgical methods are highlighted. |
| Publish Date |
2024-06-19 10:24 |
| Citation |
<p>Barkhordarian M, Tran HHV, Menon A, Pulipaka SP, Aguilar IK, Fuertes A, Dey S, Chacko AA, Sethi T, Bangolo A, Weissman S. Innovation in pathogenesis and management of aortic aneurysm. <i>World J Exp Med</i> 2024; 14(2): 91408</p> |
| URL |
https://www.wjgnet.com/2220-315x/full/v14/i2/91408.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v14.i2.91408 |
