Publication Name	World Journal of Hepatology
Manuscript ID	91414
Country	China

Received	2023-12-28 07:08
Peer-Review Started	2023-12-28 07:08
To Make the First Decision
Return for Revision	2024-01-17 12:17
Revised	2024-02-09 13:48
Second Decision	2024-04-07 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-07 04:34
Articles in Press	2024-04-07 04:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-11 02:51
Publish the Manuscript Online	2024-05-22 11:33

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Li Xu, Yu-Hong Fan, Xiao-Jing Zhang and Lan Bai
ORCID	Author(s) ORCID Number Xiao-Jing Zhang http://orcid.org/0000-0002-8271-7405 Lan Bai http://orcid.org/0000-0002-8859-1540
Funding Agency and Grant Number
Corresponding Author	Lan Bai, PhD, Professor, State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases; Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University, Huangjin Campus, University Town, Rongjiang New District, Ganzhou 341000, Jiangxi Province, China. bailan@gmu.edu.cn
Key Words	Non-alcoholic fatty liver disease; Mechanism; Histone methylation; Methyltransferases; Demethytrasferases; Epigenetic modification; Adipogenesis
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is a global health concern accounting for a significant proportion of liver-related deaths. However, there are no Food and Drug Administration-approved drugs for NAFLD treatment. Epigenetic mechanisms play multiple roles in the pathogenesis of diseases and hold promise as potential therapeutic targets. Here, we review the impact of histone methylation on the alterations in metabolic homeostasis, inflammatory injury, fibrosis, and carcinogenesis during the progression of NAFLD, providing a theoretical foundation for target discovery and clinical treatment.
Publish Date	2024-05-22 11:33
Citation	<p>Xu L, Fan YH, Zhang XJ, Bai L. Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease. <i>World J Hepatol</i> 2024; 16(5): 703-715</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i5/703.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i5.703

Full Article (PDF)	WJH-16-703-with-cover.pdf
Manuscript File	91414_Auto_Edited-YJP.docx
Answering Reviewers	91414-Answering reviewers.pdf
Audio Core Tip	91414-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91414-Conflict-of-interest statement.pdf
Copyright License Agreement	91414-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	91414-Language certificate.pdf
Peer-review Report	91414-Peer-review(s).pdf
Scientific Misconduct Check	91414-Bing-Li L-2.png
Scientific Editor Work List	91414-Scientific editor work list.pdf
CrossCheck Report	91414-CrossCheck.png
CrossCheck Report	91414-CrossCheck report.pdf