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Articles Published Processes
4/22/2024 9:51:56 AM | Browse: 110 | Download: 312
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Received |
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2023-12-28 20:56 |
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Peer-Review Started |
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2023-12-28 20:56 |
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To Make the First Decision |
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Return for Revision |
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2024-01-19 20:46 |
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Revised |
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2024-02-07 19:51 |
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Second Decision |
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2024-03-21 02:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-03-21 09:14 |
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Articles in Press |
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2024-03-21 09:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-04-11 01:41 |
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Publish the Manuscript Online |
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2024-04-22 09:51 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Comparative effectiveness of immunotherapy and chemotherapy in patients with metastatic colorectal cancer stratified by microsatellite instability status
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chen-Gu Niu, Jing Zhang, Aniket-Vijay Rao, Utsav Joshi and Patrick Okolo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chen-Gu Niu, MD, Assistant Professor, Department of Internal Medicine, Rochester General Hospital, No. 1425 Portland Avenue, Rochester, NY 14621, United States. chenguniu@gmail.com |
| Key Words |
Immunotherapy; Chemotherapy; Metastatic colorectal cancer; Microsatellite instability; National cancer database |
| Core Tip |
Our population-based study demonstrates that immunotherapy treatment is associated with significantly improved overall survival in patients with high microsatellite instability (MSI-H) metastatic colorectal cancer. However, immunotherapy does not significantly benefit patients with microsatellite stable (MSS) metastatic colorectal cancer. The lower response rates to immunotherapy in MSS tumors can be attributed to the lower tumor mutational burden and reduced immunogenicity compared to MSI-H tumors. These findings indicate that while immunotherapy is a promising treatment for MSI-H colorectal cancer, its efficacy in MSS cases remains uncertain, warranting further investigation to develop targeted therapies for these patients. |
| Publish Date |
2024-04-22 09:51 |
| Citation |
Niu CG, Zhang J, Rao AV, Joshi U, Okolo P. Comparative effectiveness of immunotherapy and chemotherapy in patients with metastatic colorectal cancer stratified by microsatellite instability status. World J Clin Oncol 2024; 15(4): 540-547 |
| URL |
https://www.wjgnet.com/2218-4333/full/v15/i4/540.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i4.540 |
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