Publication Name	World Journal of Stem Cells
Manuscript ID	91507
Country	China

Received	2024-01-06 02:11
Peer-Review Started	2024-01-06 02:11
To Make the First Decision
Return for Revision	2024-03-09 06:33
Revised	2024-03-22 12:31
Second Decision	2024-04-15 10:06
Accepted by Journal Editor-in-Chief	2024-04-21 16:34
Accepted by Executive Editor-in-Chief	2024-05-11 07:00
Articles in Press	2024-05-11 07:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-15 09:39
Publish the Manuscript Online	2024-06-25 10:11

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators
Manuscript Source	Unsolicited Manuscript
All Author List	Ying Gao, Mei-Fang Liu, Yang Li, Xi Liu, Yu-Jie Cao, Qian-Fa Long, Jun Yu and Jian-Ying Li
ORCID	Author(s) ORCID Number Jian-Ying Li http://orcid.org/0009-0004-5485-9870
Funding Agency and Grant Number	Funding Agency Grant Number Xi’an Science and Technology Plan Project 20200001YX001(1) Xi’an Talent Plan - Elite (Innovative Talents) Project XAYC210062
Corresponding Author	Jian-Ying Li, MD, Doctor, Doctor, Department of Respiratory and Critical Care Medicine, Xi’an Central Hospital, No. 163 West Fifth Road, Xi’an 710000, Shaanxi Province, China. l13572168322@163.com
Key Words	Mesenchymal stem cells; Extracellular vesicles; Pulmonary fibrosis; Oxidative stress response; Epithelial mesenchymal transition
Core Tip	This study unveils the innovative potential of mesenchymal stem cells-extracellular vesicles (MSC-EVs) in mitigating pulmonary fibrosis (PF). Notably, MSC-EVs effectively countered transforming growth factor-β1-induced fibrosis in A549 cells, showcasing a significant reduction in collagen I and alpha smooth muscle actin. The treatment exhibited a dual impact, alleviating oxidative stress and inflammatory responses in vitro. In PF mouse lungs, MSC-EVs demonstrated remarkable down-regulation of fibrotic markers and modulation of oxidative stress and inflammation.
Publish Date	2024-06-25 10:11
Citation	<p>Gao Y, Liu MF, Li Y, Liu X, Cao YJ, Long QF, Yu J, Li JY. Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators. <i>World J Stem Cells</i> 2024; 16(6): 670-689</p>
URL	https://www.wjgnet.com/1948-0210/full/v16/i6/670.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i6.670

Full Article (PDF)	WJSC-16-670-with-cover.pdf
The ARRIVE Guidelines	91507-The-ARRIVE-Guidelines.pdf
Manuscript File	91507_Auto_Edited-YJP.docx
Answering Reviewers	91507-answering-reviewers.pdf
Audio Core Tip	91507-audio.m4a
Biostatistics Review Certificate	91507-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	91507-conflict-of-interest-statement.pdf
Copyright License Agreement	91507-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91507-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	91507-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	91507-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	91507-non-native-speakers.pdf
Peer-review Report	91507-peer-reviews.pdf
Journal Editor-in-Chief Review Report	91507-journal-editor-in-chief.pdf
Scientific Misconduct Check	91507-scientific-misconduct-check.png
Scientific Editor Work List	91507-scientific-editor-work-list.pdf
CrossCheck Report	91507-crosscheck-report.pdf