Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	91523
Country	Brazil

Received	2023-12-29 21:07
Peer-Review Started	2023-12-29 21:07
To Make the First Decision
Return for Revision	2024-01-20 06:20
Revised	2024-01-26 19:58
Second Decision	2024-03-04 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-04 05:18
Articles in Press	2024-03-04 05:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-27 05:36
Publish the Manuscript Online	2024-04-11 02:23

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	New avenues for the treatment of immunotherapy-resistant pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Luis Guilherme de Oliveira Silva, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Mariana dos Santos Calmon, Gabriel Lima Correa Santos, Gabriel Reis Rocha and Fabrício Freire de Melo
ORCID	Author(s) ORCID Number Luis Guilherme de Oliveira Silva http://orcid.org/0000-0001-7275-7182 Fabian Fellipe Bueno Lemos http://orcid.org/0000-0002-4686-7086 Marcel Silva Luz http://orcid.org/0000-0003-1650-5807 Samuel Luca Rocha Pinheiro http://orcid.org/0000-0002-8877-892X Mariana dos Santos Calmon http://orcid.org/0000-0002-3871-7408 Gabriel Lima Correa Santos http://orcid.org/0000-0003-3673-9889 Gabriel Reis Rocha http://orcid.org/0000-0002-3090-0726 Fabrício Freire de Melo http://orcid.org/0000-0002-5680-2753
Funding Agency and Grant Number	Funding Agency Grant Number The Scientific Initiation Scholarship Programme (PIBIC) of National Council for Scientific and Technological Development 6511185733054315 The Scientific Initiation Scholarship Programme (PIBIC) of National Council for Scientific and Technological Development 3748771590681149 The Scientific Initiation Scholarship Programme (PIBIC) of Bahia State Research Support Foundation 19.573.301.5418 The CNPq Research Productivity Fellow 4357511882624145
Corresponding Author	Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormínio Barros, No. 58, Candeias, Vitória da Conquista 45029-094, Bahia, Brazil. freiremelo@yahoo.com.br
Key Words	Pancreatic cancer; Immunotherapy; Resistance; Tumor microenvironment; manipulation; Combined immunotherapy
Core Tip	This study aims to analyze the main mechanisms of resistance to pancreatic cancer immunotherapy and the respective methods of manipulating these processes. Thus, this review provides a compilation of the main mechanisms of resistance to immunotherapy linked to the tumor microenvironment, genetic factors and those linked to T-cell immunosuppression. Finally, this study provides an insight into new avenues that can be followed to manipulate the factors linked to resistance, providing a more efficient treatment and a reduction in lethality.
Publish Date	2024-04-11 02:23
Citation	Silva LGO, Lemos FFB, Luz MS, Rocha Pinheiro SL, Calmon MDS, Correa Santos GL, Rocha GR, de Melo FF. New avenues for the treatment of immunotherapy-resistant pancreatic cancer. World J Gastrointest Oncol 2024; 16(4): 1134-1153
URL	https://www.wjgnet.com/1948-5204/full/v16/i4/1134.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i4.1134

Full Article (PDF)	WJGO-16-1134-with-cover.pdf
Manuscript File	91523_Auto_Edited-YJP.docx
Answering Reviewers	91523-Answering reviewers.pdf
Audio Core Tip	91523-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	91523-Conflict-of-interest statement.pdf
Copyright License Agreement	91523-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91523-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	91523-Language certificate.pdf
Peer-review Report	91523-Peer-review(s).pdf
Scientific Misconduct Check	91523-Bing-Liu H-2.png
Scientific Editor Work List	91523-Scientific editor work list.pdf
CrossCheck Report	91523-CrossCheck report.pdf