| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Immunoprophylaxis failure and vaccine response in infants born to mothers with chronic hepatitis B infection in Djibouti
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sahal Darar Dirir, Ambroise D Ahouidi, Aboubacry Drame, Warsama Osman Abdi, Guelleh Youssouf Kayad, Mohamed Houmed Aboubakar, Makhtar Camara, Coumba Toure Kane and Halimatou Diop Ndiaye |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Attestation de Financement de These de Doctorat |
Dakar le 28/10/2019 |
|
| Corresponding Author |
Halimatou Diop Ndiaye, BPharm, Professor, Professor Emerita, Bacteriology and Virology Laboratory, Le Dantec University Teaching Hospital, 30 Ave Pasteur, Dakar BP 7325, Senegal. halimatoudiop@yahoo.fr |
| Key Words |
Hepatitis B surface antigen; Infants; Hepatitis B immunoglobulin; Hepatitis vaccine; Djibouti |
| Core Tip |
This study conducted in Djibouti city from January 2021 to May 2022, evaluated the effectiveness of hepatitis B virus (HBV) vaccination and immunoglobulin administration in infants born to hepatitis B surface antigen-positive mothers. Among the 50 mother-infant pairs, the mother-to-child transmission rate (MTCT) was 4%, increasing to 67% in hepatitis B e antigen (HBeAg)-positive women with a viral load > 200000 IU/mL. A seroprotective response was achieved in 84% of infants, and immunoprophylaxis failure was associated with maternal HBV DNA levels (> 200000 IU/mL) and positive HBeAg status. Despite an immunoprophylaxis failure rate higher than the World Health Organization target, this combination has been shown to be effective in preventing HBV MTCT in HBeAg-negative women, and also demonstrates the value of peripartum prophylaxis for women at risk. |
| Publish Date |
2024-07-26 10:33 |
| Citation |
<p>Darar Dirir S, Ahouidi AD, Drame A, Osman Abdi W, Youssouf Kayad G, Houmed Aboubakar M, Camara M, Toure Kane C, Diop Ndiaye H. Immunoprophylaxis failure and vaccine response in infants born to mothers with chronic hepatitis B infection in Djibouti. <i>World J Hepatol</i> 2024; 16(7): 1039-1050</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i7/1039.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i7.1039 |
