Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	91549
Country	Spain

Received	2023-12-31 18:01
Peer-Review Started	2023-12-31 18:01
To Make the First Decision
Return for Revision	2024-01-27 20:45
Revised	2024-02-09 19:02
Second Decision	2024-03-13 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-13 07:24
Articles in Press	2024-03-13 07:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-22 04:37
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Joaquina Martínez-Galán, Cristina Jiménez-Luna, Isabel Rodriguez, Elisabeth Maza, Carlos García-Collado, Antonio Rodríguez-Fernández, Javier Luis López-Hidalgo and Octavio Caba
ORCID	Author(s) ORCID Number Joaquina Martínez-Galán http://orcid.org/0000-0002-6814-2748 Cristina Jiménez-Luna http://orcid.org/0000-0002-2395-1728 Isabel Rodriguez http://orcid.org/0000-0003-4292-8731 Elisabeth Maza http://orcid.org/0009-0000-4213-9666 Carlos García-Collado http://orcid.org/0000-0002-8270-2123 Antonio Rodríguez-Fernández http://orcid.org/0000-0002-6068-3160 Javier Luis López-Hidalgo http://orcid.org/0000-0001-9106-2028 Octavio Caba http://orcid.org/0000-0003-3426-8294
Funding Agency and Grant Number
Corresponding Author	Cristina Jiménez-Luna, PhD, Senior Researcher, Institute of Biopathology and Regenerative Medicine (IBIMER), University of Granada, Avenida del Conocimiento, s/n, Granada 18016, Spain. crisjilu@ugr.es
Key Words	Pancreatic ductal adenocarcinoma; Lung cancer; Immunotherapy; Pembrolizumab; Programmed cell death protein-1; Case report
Core Tip	The lack of specific symptoms in patients and the absence of a reliable and well-stablished diagnostic method, makes advanced pancreatic ductal adenocarcinoma (PDAC) the most common clinical appearance of pancreatic cancer cases. In these circumstances, surgical resection, the only curative approach for this malignancy, is unaffordable, leading to very low survival outcomes. Immunotherapy is a recent approach that has been studied in many cancer types showing encouraging results, but it has not been sufficiently investigated in PDAC. We report the case of a patient with unresectable PDAC that progressed to metastasis after treatment with chemoradiation, who showed an outstanding response to immunotherapy with pembrolizumab, achieving a complete remission within a few months, which was maintained until the end of treatment. Currently, the patient continues in disease-free state.
Publish Date	2024-05-09 13:59
Citation	Martínez-Galán J, Jiménez-Luna C, Rodriguez I, Maza E, García-Collado C, Rodríguez-Fernández A, López-Hidalgo JL, Caba O. Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature. World J Gastrointest Oncol 2024; 16(5): 2233-2240
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/2233.htm
DOI	10.4251/wjgo.v16.i5.2233

Full Article (PDF)	WJGO-16-2233-with-cover.pdf
CARE Checklist–2016	91549-CARE Checklist (2016).pdf
Manuscript File	91549_Auto_Edited-YJP.docx
Answering Reviewers	91549-Answering reviewers.pdf
Audio Core Tip	91549-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	91549-Conflict-of-interest statement.pdf
Copyright License Agreement	91549-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	91549-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	91549-Language certificate.pdf
Peer-review Report	91549-Peer-review(s).pdf
Scientific Misconduct Check	91549-Bing-Li L-2.png
Scientific Editor Work List	91549-Scientific editor work list.pdf
CrossCheck Report	91549-CrossCheck.png
CrossCheck Report	91549-CrossCheck report.pdf