| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Circadian rhythm disruption and endocrine-related tumors
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Christos Savvidis, Efthymia Kallistrou, Eleni Kouroglou, Sofia Dionysopoulou, Georgios Gavriiloglou, Dimitra Ragia, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis and Ioannis Ilias |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ioannis Ilias, MD, PhD, Director, Director, Department of Endocrinology, Hippocration General Hospital, 63 Evrou Str, Athens GR-11527, Greece. iiliasmd@yahoo.com |
| Key Words |
Chronotherapy; Endocrine tumors; Cancer; CLOCK gene; Shift work; Circadian disruption; Circadian rhythm |
| Core Tip |
This review explores the pivotal role of circadian clocks in physiological processes and their disruption's links to adverse health outcomes, including metabolic syndrome and cancer. Orchestrated by interlocked CLOCK genes, the circadian system regulates vital functions, from sleep-wake cycles to immune response. Disruptions, often from night shift work, correlate with increased risks, notably in endocrine tumors. Molecular insights highlight potential therapeutic vistas, emphasizing the need for integrating circadian considerations in personalized healthcare. Chronotherapy emerges as a promising approach for endocrine tumor treatment, urging further research into precise mechanisms and public health interventions to mitigate lifestyle-related circadian disruptions. |
| Publish Date |
2024-07-16 06:17 |
| Citation |
Savvidis C, Kallistrou E, Kouroglou E, Dionysopoulou S, Gavriiloglou G, Ragia D, Tsiama V, Proikaki S, Belis K, Ilias I. Circadian rhythm disruption and endocrine-related tumors. World J Clin Oncol 2024; 15(7): 818-834 |
| URL |
https://www.wjgnet.com/2218-4333/full/v15/i7/818.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i7.818 |
