Publication Name	World Journal of Diabetes
Manuscript ID	91565
Country	China

Received	2023-12-31 05:26
Peer-Review Started	2023-12-31 05:26
To Make the First Decision
Return for Revision	2024-01-17 09:13
Revised	2024-01-26 13:33
Second Decision	2024-03-04 07:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-11 06:12
Articles in Press	2024-03-11 06:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-03-14 03:25
Typeset the Manuscript	2024-04-29 00:16
Publish the Manuscript Online	2024-05-10 11:51

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Estrogen restored disordered lipid metabolism in visceral fat of prediabetic mice
Manuscript Source	Invited Manuscript
All Author List	Su-Huan Liu, Zhao-Shui Shangguan, Paiziliya Maitiaximu, Zhi-Peng Li, Xin-Xin Chen and Can-Dong Li
ORCID	Author(s) ORCID Number Su-Huan Liu http://orcid.org/0000-0002-9192-2646 Can-Dong Li http://orcid.org/0009-0002-7307-9955
Funding Agency and Grant Number	Funding Agency Grant Number National and Natural Science Foundation 81270901 National and Natural Science Foundation 81970672
Corresponding Author	Can-Dong Li, MD, PhD, Chief Doctor, President, President, Professor, Research Base of Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, No. 1 Qiuyang Road, Fuzhou 350122, Fujian Province, China. fjzylcd@126.com
Key Words	Estrogen; Obesity, Visceral adiposity; Energy metabolism; Type 2 diabetes
Core Tip	It is widely accepted that adipocyte hypertrophy arises from an increase in lipogenesis and/or a reduction in lipolysis. Our findings reveal that despite the presence of adipocyte hypertrophy and visceral adiposity, the expression of genes related to both fatty acid biosynthesis and oxidation in visceral adipose tissue was significantly reduced following ovariectomy (OVX) in mice fed a high-fat diet, suggesting a comprehensive decline in metabolic activity. Remarkably, estrogen treatment fully reversed the disrupted expression patterns of lipid metabolic genes in OVX mice, correcting their disordered metabolic phenotype. This study unveils a novel mechanism underlying adipocyte adiposity and highlights estrogen's protective role against visceral obesity.
Publish Date	2024-05-10 11:51
Citation	Liu SH, Shangguan ZS, Maitiaximu P, Li ZP, Chen XX, Li CD. Estrogen restored disordered lipid metabolism in visceral fat of prediabetic mice. World J Diabetes 2024; 15(5): 988-1000
URL	https://www.wjgnet.com/1948-9358/full/v15/i5/988.htm
DOI	10.4239/wjd.v15.i5.988

Full Article (PDF)	WJD-15-988-with-cover.pdf
Full Article (Word)	WJD-15-988.docx
The ARRIVE Guidelines	91565-The ARRIVE guidelines.pdf
Manuscript File	91565_Auto_Edited-YJP_WangTQ.docx
Answering Reviewers	91565-Answering reviewers.pdf
Audio Core Tip	91565-Audio core tip.mp4
Biostatistics Review Certificate	91565-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91565-Conflict-of-interest statement.pdf
Copyright License Agreement	91565-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91565-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	91565-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	91565-Language certificate.pdf
Peer-review Report	91565-Peer-review(s).pdf
Scientific Misconduct Check	91565-Bing-Lin C-2.png
Scientific Editor Work List	91565-Scientific editor work list.pdf
CrossCheck Report	91565-CrossCheck.png
CrossCheck Report	91565-CrossCheck report.pdf