Publication Name	World Journal of Diabetes
Manuscript ID	91592
Country	China

Received	2023-12-31 07:30
Peer-Review Started	2023-12-31 07:30
To Make the First Decision
Return for Revision	2024-01-16 05:33
Revised	2024-01-22 09:14
Second Decision	2024-02-27 00:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-05 06:29
Articles in Press	2024-03-05 06:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-26 08:00
Publish the Manuscript Online	2024-04-12 01:04

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Icariin accelerates bone regeneration by inducing osteogenesis-angiogenesis coupling in rats with type 1 diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Sheng Zheng, Guan-Yu Hu, Jun-Hua Li, Jia Zheng and Yi-Kai Li
ORCID	Author(s) ORCID Number Sheng Zheng http://orcid.org/0000-0001-6525-8721 Guan-Yu Hu http://orcid.org/0000-0002-1148-0631 Jun-Hua Li http://orcid.org/0000-0001-6860-3877 Jia Zheng http://orcid.org/0000-0002-6480-3422 Yi-Kai Li http://orcid.org/0000-0003-0766-6051
Funding Agency and Grant Number	Funding Agency Grant Number National Postdoctor Grant Scheme of China GZC20231088 President Foundation of The Third Affiliated Hospital of Southern Medical University YP202210
Corresponding Author	Yi-Kai Li, MD, PhD, Chief Physician, Full Professor, Professor, Research Scientist, Department of Traditional Chinese Orthopedics and Traumatology, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, No. 183 Zhongshan Avenue West, Tianhe District, Guangzhou 510630, Guangdong Province, China. ortho@smu.edu.cn
Key Words	Icariin; Osteogenesis-angiogenesis coupling; Type 1 diabetes mellitus; Bone defect; Bone regeneration
Core Tip	Type 1 diabetes mellitus (T1DM) leads to a decrease in bone formation in a bone defect area. We demonstrated that icariin, a natural flavonoid compound monomer, accelerated bone regeneration by inducing osteogenesis-angiogenesis coupling of bone marrow mesenchymal stem cells in a T1DM rat model. This finding indicates that further investigations into the effective coupling of osteogenesis and angiogenesis should be undertaken in the field of bone regeneration in T1DM patients.
Publish Date	2024-04-12 01:04
Citation	Zheng S, Hu GY, Li JH, Zheng J, Li YK. Icariin accelerates bone regeneration by inducing osteogenesis-angiogenesis coupling in rats with type 1 diabetes mellitus. World J Diabetes 2024; 15(4): 769-782
URL	https://www.wjgnet.com/1948-9358/full/v15/i4/769.htm
DOI	https://dx.doi.org/10.4239/wjd.v15.i4.769

Full Article (PDF)	WJD-15-769-with-cover.pdf
The ARRIVE Guidelines	91592-The ARRIVE guidelines.pdf
Manuscript File	91592_Auto_Edited-YJP.docx
Answering Reviewers	91592-Answering reviewers.pdf
Audio Core Tip	91592-Audio core tip.mp3
Biostatistics Review Certificate	91592-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91592-Conflict-of-interest statement.pdf
Copyright License Agreement	91592-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91592-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	91592-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	91592-Language certificate.pdf
Peer-review Report	91592-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	91592-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	91592-Bing-Chen YL-2.png
Scientific Editor Work List	91592-Scientific editor work list.pdf
CrossCheck Report	91592-CrossCheck report.pdf