Publication Name	World Journal of Radiology
Manuscript ID	9160
Country	Italy

Received	2014-01-24 15:29
Peer-Review Started	2014-01-24 22:53
To Make the First Decision	2014-03-12 16:45
Return for Revision	2014-03-20 20:32
Revised	2014-04-13 00:05
Second Decision	2014-05-19 09:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-19 09:28
Articles in Press	2014-05-23 12:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-17 19:12
Publish the Manuscript Online	2014-06-28 15:27

ISSN	1949-8470 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Psychiatry
Manuscript Type	Frontier
Article Title	White matter abnormalities: Insights into the pathophysiology of major affective disorders
Manuscript Source	Unsolicited Manuscript
All Author List	Gianluca Serafini, Xenia Gonda, Zoltan Rihmer, Paolo Girardi and Mario Amore
Funding Agency and Grant Number
Corresponding Author	Gianluca Serafini, MD, PhD, Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, 1035-1039, Via di Grottarossa, 00189 Rome, Italy. gianluca.serafini@uniroma1.it
Key Words	White matter hyperintensities; Major affective disorders; Suicidal behaviour; Neuroimaging; Outcome
Core Tip	Understanding neural correlates underlying psychiatric morbidity over time is critical but, to date, structural magnetic resonance imaging studies identified only not stable risk predictors of unfavourable outcome in psychiatric populations. The presence of white matter hyperintensities (WMHs) has been commonly associated with a poor outcome in individuals with major affective disorders. Based on our studies, subjects with WMHs may be considered at higher suicidal risk than those without and the severity of WMHs as assessed by the Fazekas modified scale may serve as a trait marker of disease. WMHs may represent an interesting neurobiological marker between the underlying vulnerability and clinical presentation of major affective disorders.
Publish Date	2014-06-28 15:27
Citation	Serafini G, Gonda X, Rihmer Z, Girardi P, Amore M. White matter abnormalities: Insights into the pathophysiology of major affective disorders. World J Radiol 2014; 6(6): 223-229
URL	http://www.wjgnet.com/1949-8470/full/v6/i6/223.htm
DOI	http://dx.doi.org/10.4329/wjr.v6.i6.223

Full Article (PDF)	WJR-6-223.pdf
Full Article (Word)	WJR-6-223.doc
Manuscript File	9160-Review.doc
Answering Reviewers	9160-Answering reviewers.pdf
Copyright License Agreement	9160-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9160-Language certificate.pdf
Peer-review Report	9160-Peer review(s).pdf
Scientific Editor Work List	9160-Scientific editor work list.pdf