Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	91623
Country	United States

Received	2024-01-02 01:49
Peer-Review Started	2024-01-02 01:49
To Make the First Decision
Return for Revision	2024-01-25 20:53
Revised	2024-02-03 01:26
Second Decision	2024-03-20 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-20 04:45
Articles in Press	2024-03-20 04:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-22 01:24
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Case Report
Article Title	Hepatocellular carcinoma presenting as an extrahepatic mass: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Kelly Wu, Krutika Patel, Chandrasekhar Padmanabhan and Kamran Idrees
ORCID	Author(s) ORCID Number Wei Kelly Wu http://orcid.org/0000-0003-1834-5931 Kamran Idrees http://orcid.org/0000-0003-0911-4461
Funding Agency and Grant Number
Corresponding Author	Kamran Idrees, MBBS, Chief, Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, No. 2220 Pierce Avenue 597 Preston Research Building , Nashville, TN 37232, United States. kamran.idrees@vumc.org
Key Words	Extrahepatic; Metastasis; Portocaval; Lymph node; Case report
Core Tip	Hepatocellular carcinoma (HCC) metastases are typically associated with increased tumor diameter, multifocality, and vascular invasion. We report a rare case of HCC metastasis to a portocaval lymph node with initially occult hepatic primary. Our case illustrates that multimodal evaluation including alpha fetoprotein and contrast-enhanced magnetic resonance imaging may improve the sensitivity of identification of primary HCC lesions. We also reviewed the literature for HCC presenting as extrahepatic masses (18 cases: Metastatic lesions; 30 cases: Primary ectopic HCC), and discuss that, in patients with extrahepatic sites of HCC, thorough assessment for intrahepatic lesions is critical to classifying disease as metastatic HCC or ectopic HCC.
Publish Date	2024-05-09 13:59
Citation	Wu WK, Patel K, Padmanabhan C, Idrees K. Hepatocellular carcinoma presenting as an extrahepatic mass: A case report and review of literature. World J Gastrointest Oncol 2024; 16(5): 2241-2252
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/2241.htm
DOI	10.4251/wjgo.v16.i5.2241

Full Article (PDF)	WJGO-16-2241-with-cover.pdf
CARE Checklist–2016	91623-CARE Checklist (2016).pdf
Manuscript File	91623_Auto_Edited-YJP.docx
Answering Reviewers	91623-Answering reviewers.pdf
Audio Core Tip	91623-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91623-Conflict-of-interest statement.pdf
Copyright License Agreement	91623-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	91623-Informed consent statement.pdf
Peer-review Report	91623-Peer-review(s).pdf
Scientific Misconduct Check	91623-Bing-Qu XL-2.jpg
Scientific Editor Work List	91623-Scientific editor work list.pdf
CrossCheck Report	91623-CrossCheck report.pdf