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Articles Published Processes
6/15/2024 2:49:04 AM | Browse: 126 | Download: 623
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Received |
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2024-01-01 09:08 |
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Peer-Review Started |
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2024-01-01 09:08 |
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First Decision by Editorial Office Director |
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2024-02-24 07:14 |
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Return for Revision |
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2024-02-25 11:20 |
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Revised |
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2024-03-14 13:17 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-04-23 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-04-23 07:45 |
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Articles in Press |
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2024-04-23 07:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-05-14 12:47 |
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Publish the Manuscript Online |
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2024-06-15 02:49 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Ying Jian, Zi-Cheng Liang, Huan Wen, Zhen Zhang and Pu-Hua Zeng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82074425 |
| Hunan Science and Technology Planning Project |
2016SK2051, 2023SK2057 |
| Hunan Provincial Administration of Traditional Chinese Medicine Research Project |
B2023089 |
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| Corresponding Author |
Zhen Zhang, PhD, Doctor, Doctor, Hunan Provincial Hospital of Integrated Traditional Chinese and Western, Cancer Research Institute of Hunan Academy of Traditional Chinese Medicine, Hunan Academy of Chinese Medicine, No. 58 Lushan Road, Changsha 410208, Hunan Province, China. zhangzhen@stu.hnucm.edu.cn |
| Key Words |
Shi-pi-xiao-ji formula; Hepatocellular carcinoma; Cellular stiffness; Plasma membrane cholesterol level; Acetyl-coA acetyltransferase 1 |
| Core Tip |
Cellular stiffness is a key feature of cellular biomechanics and is determined by cholesterol levels in the plasma membrane. Traditional Chinese medicine (TCM) has demonstrated good anti-tumor effects, but underlying mechanisms are not well characterized. Herein, we investigated the effects of the Shi-pi-xiao-ji (SPXJ) herbal formula on the stiffness of hepatocellular carcinoma (HCC) cells. The SPXJ formula altered the stiffness of HCC cells by decreasing plasma membrane cholesterol levels through upregulation of acetyl-coA acetyltransferase 1. Subsequently, this inhibited the invasion and metastasis of HCC cells. Our study provides a scientific basis for the clinical use of TCM preparations in the treatment of HCC. |
| Publish Date |
2024-06-15 02:49 |
| Citation |
Jian HY, Liang ZC, Wen H, Zhang Z, Zeng PH. Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1. World J Gastrointest Oncol 2024; 16(6): 2727-2741 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i6/2727.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i6.2727 |
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