Publication Name	World Journal of Clinical Oncology
Manuscript ID	91648
Country	China

Received	2024-01-02 02:01
Peer-Review Started	2024-01-02 03:04
To Make the First Decision
Return for Revision	2024-01-20 09:32
Revised	2024-02-01 17:30
Second Decision	2024-03-20 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-20 05:17
Articles in Press	2024-03-20 05:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-11 01:49
Publish the Manuscript Online	2024-04-22 09:51

ISSN	2218-4333 (online)
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Regulation of TMEM100 expression by epigenetic modification, effects on proliferation and invasion of esophageal squamous carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yue-Feng Xu, Yan Dang, Wei-Bo Kong, Han-Lin Wang, Xiu Chen, Long Yao, Yuan Zhao and Ren-Quan Zhang
ORCID	Author(s) ORCID Number Ren-Quan Zhang http://orcid.org/0000-0001-5342-8498
Funding Agency and Grant Number
Corresponding Author	Ren-Quan Zhang, MD, Surgeon, Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Ji Xi Road , Hefei 230000, Anhui Province, China. zhangrenquanayfy@163.com
Key Words	Esophageal squamous cell carcinoma; TMEM100; Invasion; Mitogen-activated protein kinases pathway; Epigenetic
Core Tip	TMEM100 has been shown to be an oncogene in a variety of tumors, but there are no reports on the role of TMEM100 in esophageal cancer. In the present study, we found that TMEM100 was lowly expressed in esophageal squamous cell carcinoma (ESCC). Methylation may play a key role in regulating TMEM100 protein low expression. Overexpression of TMEM100 resulted in its increased expression in ESCC cells. Overexpression of TMEM100 also inhibited proliferation, invasion and migration of ESCC cells. Low expression of TMEM100 in ESCC may lead to aberrant activation of the mitogen-activated protein kinases pathway.
Publish Date	2024-04-22 09:51
Citation	Xu YF, Dang Y, Kong WB, Wang HL, Chen X, Yao L, Zhao Y, Zhang RQ. Regulation of TMEM100 expression by epigenetic modification, effects on proliferation and invasion of esophageal squamous carcinoma. World J Clin Oncol 2024; 15(4): 554-565
URL	https://www.wjgnet.com/2218-4333/full/v15/i4/554.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i4.554

Full Article (PDF)	WJCO-15-554-with-cover.pdf
Manuscript File	91648_Auto_Edited-YJP.docx
Answering Reviewers	91648-Answering reviewers.pdf
Audio Core Tip	91648-Audio core tip.aac
Biostatistics Review Certificate	91648-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91648-Conflict-of-interest statement.pdf
Copyright License Agreement	91648-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	91648-Language certificate.pdf
Peer-review Report	91648-Peer-review(s).pdf
Scientific Misconduct Check	91648-Bing-Luo ML-2.png
Scientific Editor Work List	91648-Scientific editor work list.pdf
CrossCheck Report	91648-CrossCheck report.pdf