| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Non-pancreatic hyperlipasemia: A puzzling clinical entity
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Krisztina Eszter Feher, David Tornai, Zsuzsanna Vitalis, Laszlo Davida, Nora Sipeki and Maria Papp |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Economic Development and Innovation Operative Program Grant |
GINOP 2.3.2- 15-2016-00048 “StayAlive” |
| Human Resources Development Operational Program Grant of the National Research Development and Innovation Office |
EFOP-3.6.2-16-2017-00006 |
|
| Corresponding Author |
Maria Papp, DSc, FEBG, MD, PhD, Professor, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Blv 98, Debrecen H-4032, Hajdu-Bihar, Hungary. papp.maria@med.unideb.hu |
| Key Words |
Non-pancreatic hyperlipasemia; Acute pancreatitis; Glycoprotein 2; Acute kidney injury; Sepsis; Mortality |
| Core Tip |
Non-pancreatic hyperlipasemia is a common and puzzling clinical entity in the differential diagnosis of acute pancreatitis (AP). The etiology of NPHL varies; however, sepsis and acute kidney injury (AKI) are the most prevalent causes. NPHL was associated with a high in-hospital mortality rate (22.4%). A readily available laboratory marker, the neutrophil-to-lymphocyte ratio, with a cut-off value > 10.37, has been the best independent laboratory predictor of mortality, with a nearly 4-fold increased risk. In the laboratory diagnosis of AP, the presence of complications, especially sepsis and AKI, warrants clinical attention, as it has a significant negative impact on the diagnostic accuracy of lipase. |
| Publish Date |
2024-05-20 09:15 |
| Citation |
Feher KE, Tornai D, Vitalis Z, Davida L, Sipeki N, Papp M. Non-pancreatic hyperlipasemia: A puzzling clinical entity. World J Gastroenterol 2024; 30(19): 2538-2552 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i19/2538.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i19.2538 |
