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Articles Published Processes
5/9/2024 1:59:12 PM | Browse: 97 | Download: 403
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Received |
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2024-01-02 10:52 |
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Peer-Review Started |
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2024-01-02 10:52 |
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First Decision by Editorial Office Director |
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2024-01-10 19:20 |
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Return for Revision |
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2024-01-12 08:31 |
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Revised |
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2024-01-19 09:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-03-07 03:11 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-03-07 06:53 |
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Articles in Press |
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2024-03-07 06:53 |
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Edit the Manuscript by Language Editor |
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2024-03-06 04:32 |
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Typeset the Manuscript |
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2024-04-23 08:45 |
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Publish the Manuscript Online |
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2024-05-09 13:59 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Immunomodulation of adipose-derived mesenchymal stem cells on peripheral blood mononuclear cells in colorectal cancer patients with COVID-19
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Feng Wang, Xiao-Xia Yang, Jian Zhang, Yan Zheng, Fu-Qing Zhang, Xiao-Feng Shi and Yu-Liang Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81470982 |
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| Corresponding Author |
Yu-Liang Wang, MD, PhD, Director, Director, Department of Clinical Laboratory Medicine, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, No. 22 Pingjiang Road, Hexi Distinct, Tianjin 300211, China. wang_yu_l@163.com |
| Key Words |
Immunomodulation; T helper cell; Adipose-derived mesenchymal stem cells; Coronavirus disease 2019; Colorectal cancer |
| Core Tip |
In patients with colorectal cancer (CRC) who develop severe coronavirus disease 2019, peripheral blood mononuclear cells display a severe pro-inflammatory phenotype and corresponding functional cytokine profile upon deliberate in vitro stimulation. Adipose tissue-derived mesenchymal stem cells (ADSCs) can significantly induce a regulatory T cell-biased immunosuppressive response while concurrently restraining exaggerated T helper 1 (Th1)-predominant and Th17 pro-inflammatory responses. These results indicate the protective immunomodulatory activity of proactive ADSC therapy by manipulating Th cell polarization to create an anti-inflammatory environment against severe acute respiratory syndrome coronavirus 2-induced severe hyperinflammatory responses. |
| Publish Date |
2024-05-09 13:59 |
| Citation |
Wang JF, Yang XX, Zhang J, Zheng Y, Zhang FQ, Shi XF, Wang YL. Immunomodulation of adipose-derived mesenchymal stem cells on peripheral blood mononuclear cells in colorectal cancer patients with COVID-19. World J Gastrointest Oncol 2024; 16(5): 2113-2122 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i5/2113.htm |
| DOI |
10.4251/wjgo.v16.i5.2113 |
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