Publication Name	World Journal of Gastroenterology
Manuscript ID	9169
Country	Italy

Received	2014-02-24 21:11
Peer-Review Started	2014-02-26 09:45
To Make the First Decision	2014-04-02 19:38
Return for Revision	2014-04-12 06:39
Revised	2014-05-02 17:42
Second Decision	2014-07-30 10:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-30 10:10
Articles in Press	2014-07-30 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-18 18:16
Publish the Manuscript Online	2014-10-07 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Nonalcoholic fatty liver disease and vascular disease: State-of-the-art
Manuscript Source	Invited Manuscript
All Author List	Silvia Fargion, Marianna Porzio and Anna Ludovica Fracanzani
Funding Agency and Grant Number
Corresponding Author	Silvia Fargion, Professor of Medicine, Department of Pathophysiology and Transplantation, Metabolic Liver Diseases Research Center, Ca’ Granda IRCCS Foundation, Policlinico Hospital Pad Granelli, via F Sforza 35, 20122 Milano, Italy. silvia.fargion@unimi.it
Key Words	Intima-media thickness; Steatosis; Nonalcoholic fatty liver disease; Non-alcoholic steatohepatitis; Early atherosclerosis; Cardiovascular risk; Inflammation; Epicardic fat
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is emerging as an independent risk factor for the occurrence and progression of cardiovascular disease. In this review we have systematically analyzed the correlation between NAFLD and cardiovascular diseases (CVD) focusing on the different aspects of CVD (increased carotid intima media thickness, increased arterial stiffness, endhotelial dysfunction, impaired left ventricular function, coronary calcification, epicardic fat), on the clinical manifestations (obstructive sleep apnea syndrome, clinical consequences of microangiopathy), and on the underlying physiopathogenic mechanisms (insulin resistance, atherogenic dyslipidemia, inflammation, oxidative stress, adipokynes imbalance, coagulation imbalance, increased assumption of fructose). Furthermore, we emphasized that NAFLD, by itself, is probably an independent risk factor for the occurrence of CVD.
Publish Date	2014-10-07 17:32
Citation	Fargion S, Porzio M, Fracanzani AL. Nonalcoholic fatty liver disease and vascular disease: State-of-the-art. World J Gastroenterol 2014; 20(37): 13306-13324
URL	http://www.wjgnet.com/1007-9327/full/v20/i37/13306.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i37.13306

Full Article (PDF)	WJG-20-13306.pdf
Full Article (Word)	WJG-20-13306.doc
Manuscript File	9169-Review.doc
Answering Reviewers	9169-Answering reviewers.pdf
Copyright License Agreement	9169-Copyright assignment.pdf
Peer-review Report	9169-Peer review.pdf
Scientific Misconduct Check	9169-CorssCheck.jpg
Scientific Editor Work List	9169-Scientific editor work list.pdf