Publication Name	World Journal of Clinical Cases
Manuscript ID	91690
Country	China

Received	2024-01-07 08:51
Peer-Review Started	2024-01-07 08:51
To Make the First Decision
Return for Revision	2024-03-05 23:42
Revised	2024-03-19 05:43
Second Decision	2024-04-09 03:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-09 08:57
Articles in Press	2024-04-09 08:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-27 15:43
Publish the Manuscript Online	2024-05-29 12:34

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Causal relationships between gut microbiota and dementia: A two-sample, bidirectional, Mendelian randomization study
Manuscript Source	Unsolicited Manuscript
All Author List	Zhao-Lin Ren, Hai-Hong Zhou, Chu-Pei Chen, Hao He, Duo-Lao Wang and Zhou Liu
ORCID	Author(s) ORCID Number Zhao-Lin Ren http://orcid.org/0009-0001-4608-4727 Hai-Hong Zhou http://orcid.org/0000-0002-0060-6534 Chu-Pei Chen http://orcid.org/0009-0004-0025-098X Hao He http://orcid.org/0009-0004-4729-4170 Duo-Lao Wang http://orcid.org/0000-0003-2788-2464 Zhou Liu http://orcid.org/0000-0002-5698-3945
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Planning Project of Zhanjiang 2021A05071 Clinic and Basic Research Project of Guangdong Medical University 4SG23284G Affiliated Hospital of Guangdong Medical University LCYJ2018A003
Corresponding Author	Zhou Liu, MD, Associate Chief Physician, Deputy Director, Department of Neurology, Affiliated Hospital of Guangdong Medical University, No. 57 People's Avenue South, Zhanjiang 524000, Guangdong Province, China. liuzhou@gdmu.edu.cn
Key Words	Mendelian randomization; FinnGen; MiBioGen; Gut microbiota; Dementia; Alzheimer’s disease; Vascular dementia
Core Tip	We identified several gut microbiota taxa as being associated with the risk of or protection against dementia, including its subtypes. These gut microbiota also exhibited potential as therapeutic targets for the disease. Conversely, reverse Mendelian randomization analysis indicated that dementia or its subtypes also influenced the abundance of several gut bacteria, implying that these taxa may serve as biomarkers for assessing the occurrence and progression of dementia. This study offers novel insights into the mechanisms underlying the role of the gut microbiome in this disorder.
Publish Date	2024-05-29 12:34
Citation	<p>Ren ZL, Zhou HH, Chen CP, He H, Wang DL, Liu Z. Causal relationships between gut microbiota and dementia: A two-sample, bidirectional, Mendelian randomization study. <i>World J Clin Cases</i> 2024; 12(16): 2780-2788</p>
URL	https://www.wjgnet.com/2307-8960/full/v12/i16/2780.htm
DOI	https://dx.doi.org/10.12998/wjcc.v12.i16.2780

Full Article (PDF)	WJCC-12-2780-with-cover.pdf
Manuscript File	91690_Auto_Edited-YJP.docx
Answering Reviewers	91690-Answering reviewers.pdf
Audio Core Tip	91690-Audio core tip.mp3
Biostatistics Review Certificate	91690-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91690-Conflict-of-interest statement.pdf
Copyright License Agreement	91690-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91690-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	91690-Language certificate.pdf
Supplementary Material	91690-Supplementary material.rar
Peer-review Report	91690-Peer-review(s).pdf
Scientific Misconduct Check	91690-Bing-Che XX-2.png
Scientific Editor Work List	91690-Scientific editor work list.pdf
CrossCheck Report	91690-CrossCheck report.pdf