Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	91750
Country	China

Received	2024-01-04 07:18
Peer-Review Started	2024-01-04 07:18
To Make the First Decision
Return for Revision	2024-03-31 04:49
Revised	2024-04-10 07:43
Second Decision	2024-04-22 02:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-22 05:51
Articles in Press	2024-04-22 05:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-14 07:42
Publish the Manuscript Online	2024-05-23 09:40

ISSN	1948-9366 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Guo-Feng Chen, Jun Wang, Yu Yan, Song Xu and Jian Chen
ORCID	Author(s) ORCID Number Guo-Feng Chen http://orcid.org/0000-0003-1927-088X Jian Chen http://orcid.org/0000-0002-2542-9669
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Provincial Key Project of Research and Development No. 2019C03043 National Natural Science Foundation of China No. 82203452 Health Science and Technology Plan of Zhejiang Province No. 2022RC165 Clinical Research Fund of Zhejiang Medical Association No. 2021ZYC-A68
Corresponding Author	Jian Chen, MD, PhD, Director, Director, Department of Gastroenterology Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310000, Zhejiang Province, China. zrchenjian@zju.edu.cn
Key Words	Stomach neoplasm; Pulmonary lymphoepithelioma-like carcinoma; Metastasis; Immune checkpoint inhibitor; Case report
Core Tip	Pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare type of non-small-cell lung cancer. Stomach LELC metastasis secondary to PLELC has not been reported recently. We present a 64-year-old female patient who was admitted to our hospital for a regular gastroscopy examination with a 6-year history of surgical resection for left PLELC. After proximal gastrectomy, histopathological examination showed a poorly differentiated carcinoma with prominent lymphoplasmacytic infiltration, suggesting stomach LELC metastasis. Tumor programmed cell death ligand 1 (PD-L1) expression showed a tumor proportion score of 98% and a combined positive score of 100. After discharge, this patient underwent PD-1 inhibitor treatment for ten cycles and has not experienced tumor recurrence. These findings suggest that for gastric LELC metastasis, PD-1 inhibitor therapy could become a potential therapeutic approach.
Publish Date	2024-05-23 09:40
Citation	<p>Chen GF, Wang J, Yan Y, Xu S, Chen J. Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy: A case report. <i>World J Gastrointest Surg</i> 2024; 16(5): 1436-1442</p>
URL	https://www.wjgnet.com/1948-9366/full/v16/i5/1436.htm
DOI	https://dx.doi.org/10.4240/wjgs.v16.i5.1436

Full Article (PDF)	WJGS-16-1436-with-cover.pdf
CARE Checklist–2016	91750-CARE Checklist (2016).pdf
Manuscript File	91750_Auto_Edited-YJP.docx
Answering Reviewers	91750-Answering reviewers.pdf
Audio Core Tip	91750-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91750-Conflict-of-interest statement.pdf
Copyright License Agreement	91750-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91750-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	91750-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	91750-Language certificate.pdf
Peer-review Report	91750-Peer-review(s).pdf
Scientific Misconduct Check	91750-Bing-Chen YL-2.png
Scientific Editor Work List	91750-Scientific editor work list.pdf
CrossCheck Report	91750-CrossCheck report.pdf