Publication Name	World Journal of Gastroenterology
Manuscript ID	91770
Country	Croatia

Received	2024-01-04 16:10
Peer-Review Started	2024-01-04 16:10
To Make the First Decision
Return for Revision	2024-01-17 02:02
Revised	2024-01-29 19:34
Second Decision	2024-03-13 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-13 06:05
Articles in Press	2024-03-13 06:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-28 05:01
Publish the Manuscript Online	2024-04-03 07:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Growth Differentiation Factor-15 Serum Concentrations Reflect Disease Severity and Anemia in Patients with Inflammatory Bowel Disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ante Tonkic, Marko Kumric, Ivna Akrapovic Olic, Doris Rusic, Piero Marin Zivkovic, Daniela Supe Domic, Zeljko Sundov, Ivan Males and Josko Bozic
ORCID	Author(s) ORCID Number Marko Kumric http://orcid.org/0000-0002-9696-3359 Doris Rusic http://orcid.org/0000-0002-7018-4947 Piero Marin Zivkovic http://orcid.org/0000-0001-5649-698X Josko Bozic http://orcid.org/0000-0003-1634-0635
Funding Agency and Grant Number
Corresponding Author	Josko Bozic, MD, PhD, Associate Professor, Department of Pathophysiology, University of Split School of Medicine, 2 Soltanska, Split 21000, Croatia. josko.bozic@mefst.hr
Key Words	Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Growth-differentiation factor-15; Anemia; Extraintestinal manifestations
Core Tip	Serum concentrations of growth-differentiation factor-15 (GDF-15) exhibit a significant elevation in inflammatory bowel disease (IBD) patients compared to healthy controls, irrespective of Crohn’s disease or ulcerative colitis diagnosis. GDF-15 levels independently predict disease severity and demonstrate an association with anemia indices, indicating its potential as a biomarker for IBD pathophysiology. Further exploration is nonetheless warranted to determine the prognostic value of GDF-15 in predicting outcomes for patients with IBD.
Publish Date	2024-04-03 07:21
Citation	Tonkic A, Kumric M, Akrapovic Olic I, Rusic D, Zivkovic PM, Supe Domic D, Sundov Z, Males I, Bozic J. Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease. World J Gastroenterol 2024; 30(13): 1899-1910
URL	https://www.wjgnet.com/1007-9327/full/v30/i13/1899.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i13.1899

Full Article (PDF)	WJG-30-1899-with-cover.pdf
STROBE Statement	91770-STROBE statement.pdf
Manuscript File	91770_Auto_Edited-YJP.docx
Answering Reviewers	91770-Answering reviewers.pdf
Audio Core Tip	91770-Audio core tip.m4a
Biostatistics Review Certificate	91770-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91770-Conflict-of-interest statement.pdf
Copyright License Agreement	91770-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	91770-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	91770-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	91770-Language certificate.pdf
Peer-review Report	91770-Peer-review(s).pdf
Scientific Misconduct Check	91770-Bing-Chen YL-2.png
Scientific Editor Work List	91770-Scientific editor work list.pdf
CrossCheck Report	91770-CrossCheck report.pdf