Publication Name	World Journal of Gastroenterology
Manuscript ID	91770
Country	Croatia

Received	2024-01-04 16:10
Peer-Review Started	2024-01-04 16:10
First Decision by Editorial Office Director	2024-01-17 02:02
Return for Revision	2024-01-17 02:02
Revised	2024-01-29 19:34
Publication Fee Transferred
Second Decision by Editor	2024-03-13 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-03-13 06:05
Articles in Press	2024-03-13 06:05
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-28 05:01
Publish the Manuscript Online	2024-04-03 07:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Growth Differentiation Factor-15 Serum Concentrations Reflect Disease Severity and Anemia in Patients with Inflammatory Bowel Disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ante Tonkic, Marko Kumric, Ivna Akrapovic Olic, Doris Rusic, Piero Marin Zivkovic, Daniela Supe Domic, Zeljko Sundov, Ivan Males and Josko Bozic
ORCID	Author(s) ORCID Number Marko Kumric http://orcid.org/0000-0002-9696-3359 Doris Rusic http://orcid.org/0000-0002-7018-4947 Piero Marin Zivkovic http://orcid.org/0000-0001-5649-698X Josko Bozic http://orcid.org/0000-0003-1634-0635
Funding Agency and Grant Number
Corresponding Author	Josko Bozic, MD, PhD, Associate Professor, Department of Pathophysiology, University of Split School of Medicine, 2 Soltanska, Split 21000, Croatia. josko.bozic@mefst.hr
Key Words	Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Growth-differentiation factor-15; Anemia; Extraintestinal manifestations
Core Tip	Serum concentrations of growth-differentiation factor-15 (GDF-15) exhibit a significant elevation in inflammatory bowel disease (IBD) patients compared to healthy controls, irrespective of Crohn’s disease or ulcerative colitis diagnosis. GDF-15 levels independently predict disease severity and demonstrate an association with anemia indices, indicating its potential as a biomarker for IBD pathophysiology. Further exploration is nonetheless warranted to determine the prognostic value of GDF-15 in predicting outcomes for patients with IBD.
Publish Date	2024-04-03 07:21
Citation	Tonkic A, Kumric M, Akrapovic Olic I, Rusic D, Zivkovic PM, Supe Domic D, Sundov Z, Males I, Bozic J. Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease. World J Gastroenterol 2024; 30(13): 1899-1910
URL	https://www.wjgnet.com/1007-9327/full/v30/i13/1899.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i13.1899

Full Article (PDF)	WJG-30-1899-with-cover.pdf