Publication Name	World Journal of Gastroenterology
Manuscript ID	91784
Country	China

Received	2024-01-05 07:54
Peer-Review Started	2024-01-05 07:54
First Decision by Editorial Office Director	2024-01-22 05:45
Return for Revision	2024-01-22 05:45
Revised	2024-02-02 12:24
Publication Fee Transferred
Second Decision by Editor	2024-03-14 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-03-14 04:04
Articles in Press	2024-03-14 04:04
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-11 05:55
Publish the Manuscript Online	2024-04-19 08:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1-p62/SQSTM1 complex
Manuscript Source	Unsolicited Manuscript
All Author List	Nan Wang, Chao-Yang Li, Teng-Fei Yao, Xiao-Dan Kang and Hui-Shu Guo
ORCID	Author(s) ORCID Number Nan Wang http://orcid.org/0000-0002-3723-0913 Chao-Yang Li http://orcid.org/0009-0003-1699-3473 Teng-Fei Yao http://orcid.org/0009-0009-6509-8057 Xiao-Dan Kang http://orcid.org/0009-0003-4121-2317 Hui-Shu Guo http://orcid.org/0000-0001-8065-0107
Funding Agency and Grant Number	Funding Agency Grant Number the Natural Science Foundation of Liaoning Province 2022-MS-330 Key Projects in Liaoning Province 2020JH2/10300046
Corresponding Author	Hui-Shu Guo, PhD, Professor, Central Laboratory, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. guohuishu1@126.com
Key Words	OSW-1; Necroptosis; RIPK1; P62/SQSTM1; Colorectal cancer
Core Tip	Colorectal cancer (CRC) is a significant health concern worldwide, and it has severe impacts on human lives. Identifying effective drugs for CRC treatment is very important. OSW-1, which is derived from the bulbs of Ornithogalum saundersiae, exhibits potent antitumor properties. This study confirmed the inhibitory effect of OSW-1 on CRC through both in vitro and in vivo experiments. Furthermore, tandem mass tag proteomic analysis was employed to predict differentially expressed proteins and potential underlying mechanisms. Our findings suggest that OSW-1 induces necroptosis via the RIPK1/RIPK3/MLKL signaling pathway, and this effect is mediated by the RIPK1-p62/SQSTM1 complex. These results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.
Publish Date	2024-04-19 08:45
Citation	Wang N, Li CY, Yao TF, Kang XD, Guo HS. OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1-p62/SQSTM1 complex. World J Gastroenterol 2024; 30 (15): 2155-2174
URL	https://www.wjgnet.com/1007-9327/full/v30/i15/2155.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i15.2155

Full Article (PDF)	WJG-30-2155-with-cover.pdf
The ARRIVE Guidelines	91784-The ARRIVE guidelines.pdf
Manuscript File	91784_Auto_Edited-YJP.docx
Answering Reviewers	91784-Answering reviewers.pdf
Audio Core Tip	91784-Audio core tip.mp3
Biostatistics Review Certificate	91784-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91784-Conflict-of-interest statement.pdf
Copyright License Agreement	91784-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	91784-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	91784-Language certificate.pdf
Peer-review Report	91784-Peer-review(s).pdf
Scientific Misconduct Check	91784-Bing-Li L-2.png
Scientific Editor Work List	91784-Scientific editor work list.pdf
CrossCheck Report	91784-CrossCheck.png
CrossCheck Report	91784-CrossCheck report.pdf