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Articles Published Processes
6/19/2024 12:40:27 PM | Browse: 63 | Download: 166
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Received |
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2024-01-06 00:46 |
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Peer-Review Started |
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2024-01-06 00:46 |
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To Make the First Decision |
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Return for Revision |
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2024-04-08 06:59 |
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Revised |
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2024-05-05 20:08 |
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Second Decision |
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2024-05-23 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2024-05-23 06:19 |
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Articles in Press |
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2024-05-23 06:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-06-07 01:44 |
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Publish the Manuscript Online |
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2024-06-19 12:40 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Metabolic complications of psychotropic medications in psychiatric disorders: Emerging role of de novo lipogenesis and therapeutic consideration
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mohammad M Khan, Zaw Ali Khan and Mohsin Ali Khan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mohammad M Khan, PhD, Professor, Laboratory of Translational Neurology and Molecular Psychiatry, Department of Biotechnology, Era’s Lucknow Medical College and Hospital, Faculty of Science, Era University, Sarfarazganj, Hardoi Road, Lucknow 226003, India. mmkhan0@gmail.com |
| Key Words |
Psychotropic medications; Metabolic complications; De novo lipogenesis; Obesity; Diabetes; Non-alcoholic fatty liver disease |
| Core Tip |
Psychotropic medications are the first line of treatment for psychiatric disorders; however, their long-term use has been shown to induce various metabolic abnormalities including diabetes, obesity, and fatty liver disease. Although mechanism(s) underlying these metabolic abnormalities is not clear, lipid/fatty acid accumulation caused by enhanced de novo lipogenesis (DNL) could be the primary mediator. In this regard, various anti-inflammatory drugs that are used in combination therapy, have been shown to reduce DNL and the aforementioned metabolic abnormalities in laboratory animals. This suggests that DNL could be a potential pathological and therapeutic target, and a new avenue for translational research in psychiatric disorders. |
| Publish Date |
2024-06-19 12:40 |
| Citation |
<p>Khan MM, Khan ZA, Khan MA. Metabolic complications of psychotropic medications in psychiatric disorders: Emerging role of de novo lipogenesis and therapeutic consideration. <i>World J Psychiatry</i> 2024; 14(6): 767-783</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v14/i6/767.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v14.i6.767 |
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