Publication Name	World Journal of Gastroenterology
Manuscript ID	91825
Country	United States

Received	2024-01-06 11:25
Peer-Review Started	2024-01-06 11:25
To Make the First Decision
Return for Revision	2024-02-06 20:23
Revised	2024-02-16 23:40
Second Decision	2024-03-19 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-19 06:53
Articles in Press	2024-03-19 06:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-28 02:08
Publish the Manuscript Online	2024-04-03 07:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Disease clearance in ulcerative colitis: A new therapeutic target for the future
Manuscript Source	Invited Manuscript
All Author List	Syed Adeel Hassan, Neeraj Kapur, Fahad Sheikh, Anam Fahad and Somia Jamal
ORCID	Author(s) ORCID Number Syed Adeel Hassan http://orcid.org/0000-0002-8484-0319 Neeraj Kapur http://orcid.org/0000-0001-6746-3331 Fahad Sheikh http://orcid.org/0000-0001-9380-0661 Anam Fahad http://orcid.org/0009-0004-8951-6480 Somia Jamal http://orcid.org/0009-0008-1796-8903
Funding Agency and Grant Number
Corresponding Author	Syed Adeel Hassan, MBBS, MD, Research Scientist, Division of Digestive Disease and Nutrition, University of Kentucky, 800 Rose Street, Lexington, KY 40536, United States. doc.syed92@gmail.com
Key Words	Inflammatory bowel disease; Ulcerative colitis; Clinical remission; Endoscopic remission; Histological remission; Mucosal healing; Disease clearance
Core Tip	Clinical management of ulcerative colitis is guided by a combination of clinical and endoscopic measures, but histologic healing is undervalued. The current definition of disease remission is insufficient due to discrepancies in outcomes. Disease clearance (DC) is a novel emerging composite outcome defined as the simultaneous attainment of clinical, endoscopic and histologic remission. The risk of disease relapse, hospitalization and surgery is significantly lower in patients who achieve DC. It provides superior optimal disease control in the short term. Large prospective studies are needed to determine the cost effectiveness, risk-benefit ratio and impact on long-term outcomes.
Publish Date	2024-04-03 07:21
Citation	Hassan SA, Kapur N, Sheikh F, Fahad A, Jamal S. Disease clearance in ulcerative colitis: A new therapeutic target for the future. World J Gastroenterol 2024; 30(13): 1801-1809
URL	https://www.wjgnet.com/1007-9327/full/v30/i13/1801.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i13.1801

Full Article (PDF)	WJG-30-1801-with-cover.pdf
Manuscript File	91825_Auto_Edited-YJP.docx
Answering Reviewers	91825-Answering reviewers.pdf
Audio Core Tip	91825-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	91825-Conflict-of-interest statement.pdf
Copyright License Agreement	91825-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	91825-Language certificate.pdf
Peer-review Report	91825-Peer-review(s).pdf
Scientific Misconduct Check	91825-Bing-Fan JR-2.png
Scientific Editor Work List	91825-Scientific editor work list.pdf
CrossCheck Report	91825-CrossCheck report.pdf
CrossCheck Report	91825-CrossCheck.png