Publication Name	World Journal of Clinical Oncology
Manuscript ID	91882
Country	China

Received	2024-01-08 09:14
Peer-Review Started	2024-01-08 09:14
To Make the First Decision
Return for Revision	2024-04-30 06:42
Revised	2024-05-13 13:16
Second Decision	2024-06-21 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-21 06:52
Articles in Press	2024-06-21 06:52
Publication Fee Transferred	2024-07-06 04:51
Edit the Manuscript by Language Editor	2024-07-22 13:48
Typeset the Manuscript	2024-07-29 09:15
Publish the Manuscript Online	2024-08-16 08:03

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Biomarkers associated with immune-related adverse events induced by immune checkpoint inhibitors
Manuscript Source	Unsolicited Manuscript
All Author List	An-Jie Guo, Qing-Yuan Deng, Pan Dong, Lian Zhou and Lei Shi
ORCID	Author(s) ORCID Number Lian Zhou http://orcid.org/0000-0002-6144-9210 Lei Shi http://orcid.org/0000-0003-3524-7970
Funding Agency and Grant Number	Funding Agency Grant Number Fundamental Research Funds for the Central Universities 2019CDYGYB024 National Natural Science Foundation of China 31300726 Chongqing Primary and Middle School Innovation Talent Training Project CY220113
Corresponding Author	Lian Zhou, Head and Neck Cancer Center, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Shapingba District, Chongqing 400000, China. zhoulianeve@163.com
Key Words	Immunotherapy; Immune checkpoint inhibitors; Immune-related adverse events; Biomarkers; Cancers
Core Tip	The development of effective biomarkers for precise immune-related adverse events (irAEs) prediction and diagnosis is urgently needed. Therefore, a comprehensive review of current studies on irAEs biomarkers is essential. This review encompasses major irAEs and provides an overview of existing biomarkers for prediction, diagnosis, and prognosis. Additionally, it explores diverse approaches for identifying novel, reliable biomarkers, including machine learning, single-cell RNA sequencing, multi-omics analysis, and gut microbiota assessment. Lastly, the review delves into the mechanisms underlying irAEs to enhance comprehension and guide the prediction, diagnosis, and management of these events.
Publish Date	2024-08-16 08:03
Citation	<p>Guo AJ, Deng QY, Dong P, Zhou L, Shi L. Biomarkers associated with immune-related adverse events induced by immune checkpoint inhibitors. <i>World J Clin Oncol</i> 2024; 15(8): 1002-1020</p>
URL	https://www.wjgnet.com/2218-4333/full/v15/i8/1002.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i8.1002

Full Article (PDF)	WJCO-15-1002-with-cover.pdf
Manuscript File	91882_Auto_Edited_012722.docx
Answering Reviewers	91882-answering-reviewers.pdf
Audio Core Tip	91882-audio.mp3
Conflict-of-Interest Disclosure Form	91882-conflict-of-interest-statement.pdf
Copyright License Agreement	91882-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	91882-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	91882-non-native-speakers.pdf
Peer-review Report	91882-peer-reviews.pdf
Scientific Misconduct Check	91882-scientific-misconduct-check.png
Scientific Editor Work List	91882-scientific-editor-work-list.pdf
CrossCheck Report	91882-crosscheck-report.pdf