| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming He, Ye Qi, Ze-Mao Zheng, Min Sha, Xiang Zhao, Yu-Rao Chen, Zheng-Hai Chen, Rong-Yu Qian, Juan Yao and Zheng-Dong Yang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Innovative Team of Jiangsu Province |
CXTDA2017042 |
| Jiangsu Provincial Medical Youth Talent |
QNRC2016508 |
| In-hospital project of Taizhou People's Hospital |
ZL201930 |
|
| Corresponding Author |
Juan Yao, MD, Chief Doctor, Department of Radiation Oncology, Huai’an Hospital of Huai’an, No. 19 Shanyang Avenue, Huai’an District, Huai’an 223299, Jiangsu Province, China. tzsry110120@163.com |
| Key Words |
Steroid receptor RNA activator 1; Esophageal squamous cell carcinoma; Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; Cancer therapy; MicroRNA; Long non-coding RNA |
| Core Tip |
In this study, we identified abnormal expression of steroid receptor RNA activator 1 (SRA1) in esophageal squamous cell carcinoma (ESCC). SRA1 was significantly downregulated in ESCC tissues and cell lines, and its low expression was strongly associated with advanced tumor stage, metastasis, larger tumor size, and poor survival. Functional and rescue assays demonstrated that SRA1 could impede ESCC cell proliferation and glycolysis via miRNA-363-5p and phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP). Mechanistically, SRA1 elevated LHPP expression by sponging miRNA-363-5p, thereby inhibiting ESCC cell proliferation and glycolysis. |
| Publish Date |
2024-09-26 10:17 |
| Citation |
<p>He M, Qi Y, Zheng ZM, Sha M, Zhao X, Chen YR, Chen ZH, Qian RY, Yao J, Yang ZD. Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma. <i>World J Gastrointest Oncol</i> 2024; 16(10): 4194-4208</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i10/4194.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i10.4194 |
