BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
5/23/2024 9:40:29 AM | Browse: 197 | Download: 346
 |
Received |
|
2024-01-10 00:35 |
|
Peer-Review Started |
|
2024-01-10 00:35 |
|
First Decision by Editorial Office Director |
|
2024-01-31 06:00 |
|
Return for Revision |
|
2024-02-02 02:07 |
|
Revised |
|
2024-02-22 06:41 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2024-04-11 02:33 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2024-04-11 06:01 |
|
Articles in Press |
|
2024-04-11 06:01 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2024-05-14 07:42 |
|
Publish the Manuscript Online |
|
2024-05-23 09:40 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qiu-Xiao Yu, Ping-Ying Fu, Chi Zhang, Li Li and Wen-Ting Huang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
82002829 |
|
| Corresponding Author |
Wen-Ting Huang, MD, Chief, Chief Doctor, Professor, Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 113 Baohe Avenue, Longgang, Shenzhen 518116, Guangdong Province, China. huangwt@cicams.ac.cn |
| Key Words |
Colorectal cancer; MET; Amplification; Pathological features; Prognosis; Fluorescence in situ hybridization |
| Core Tip |
This study aimed to investigate pathological significance of mesenchymal-epithelial transition factor (MET) amplification in therapy-naïve colorectal cancer (CRC) and to propose a feasible screening strategy in clinical practice. In CRC harboring no RAS/RAF mutation or microsatellite instability, focal MET amplification was a rare event, while polysomy-caused MET amplification was observed in 14.4% of patients. Polysomy-caused MET amplification significantly correlated with frequent lymph node metastasis and higher tumor budding grade, which were two independent predictors of unfavorable CRC survival. Consistently, we discovered that MET amplification predicted poor outcome in a two-year follow-up. To our knowledge, this study firstly proved that c-MET immunohistochemistry (IHC) was not a suitable screening tool for MET amplification in CRC, and we recommend that tissue should be prioritized for fluorescence in situ hybridization over IHC to determine MET amplification. |
| Publish Date |
2024-05-23 09:40 |
| Citation |
Yu QX, Fu PY, Zhang C, Li L, Huang WT. Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer. World J Gastrointest Surg 2024; 16(5): 1395-1406 |
| URL |
https://www.wjgnet.com/1948-9366/full/v16/i5/1395.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v16.i5.1395 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
