Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	91958
Country	China

Received	2024-01-11 15:40
Peer-Review Started	2024-01-11 15:40
First Decision by Editorial Office Director	2024-01-30 21:54
Return for Revision	2024-01-30 21:54
Revised	2024-02-19 08:45
Publication Fee Transferred
Second Decision by Editor	2024-03-13 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-03-13 07:19
Articles in Press	2024-03-13 07:19
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-22 04:36
Publish the Manuscript Online	2024-05-09 13:59

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1- extracellular signal-regulated kinase-1/2 axis
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Xia Bai, Xue-Mei Qiu, Chun-Hong Xu and Jian-Qiang Guo
ORCID	Author(s) ORCID Number Jian-Qiang Guo http://orcid.org/0000-0003-4164-2774
Funding Agency and Grant Number
Corresponding Author	Jian-Qiang Guo, MD, PhD, Chief Physician, Director, Director, Senior Researcher, Department of Gastroenterology, The Second Hospital of Shandong University, No. 247 Beiyuan Street, Tianqiao District, Jinan 250000, Shandong Province, China. guo_jianqiang@126.com
Key Words	Gastric cancer; MicroRNA-145-5p; Serpin family E member 1; Epithelial-mesenchymal transition; Proliferation; Extracellular signal-regulated kinase-1/2
Core Tip	Abnormal microRNAs (miRNAs) expression is found in multiple diseases, including cancer, where it contributes to tumor progression. The exact role of miRNA-145-5p (miR-145-5p) in gastric cancer (GC) remains poorly understood. The current study assessed the molecular pathways used by miR-145-5p to regulate GC in tumor tissues, cell lines, and a nude mouse model. MiR-145-5p was shown to target serpin family E member 1, regulate the extracellular signal-regulated kinase-1/2 pathway, and directly impact GC progression, playing an important role in this disease. The findings identify the molecular mechanism of GC progression.
Publish Date	2024-05-09 13:59
Citation	Bai HX, Qiu XM, Xu CH, Guo JQ. MiR-145-5p inhibits gastric cancer progression via the serpin family E member 1- extracellular signal-regulated kinase-1/2 axis. World J Gastrointest Oncol 2024; 16(5): 2123-2140
URL	https://www.wjgnet.com/1948-5204/full/v16/i5/2123.htm
DOI	10.4251/wjgo.v16.i5.2123

Full Article (PDF)	WJGO-16-2123-with-cover.pdf
The ARRIVE Guidelines	91958-The ARRIVE guidelines.pdf
Manuscript File	91958_Auto_Edited-YJP.docx
Answering Reviewers	91958-Answering reviewers.pdf
Audio Core Tip	91958-Audio core tip.mp3
Biostatistics Review Certificate	91958-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91958-Conflict-of-interest statement.pdf
Copyright License Agreement	91958-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	91958-Institutional animal care and use committee statement_1.pdf
Institutional Review Board Approval Form or Document	91958-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	91958-Language certificate.pdf
Peer-review Report	91958-Peer-review(s).pdf
Scientific Misconduct Check	91958-Bing-Qu XL-2.jpg
Scientific Editor Work List	91958-Scientific editor work list.pdf
CrossCheck Report	91958-CrossCheck report.pdf