Publication Name	World Journal of Gastroenterology
Manuscript ID	91961
Country	China

Received	2024-01-19 07:23
Peer-Review Started	2024-01-19 07:24
To Make the First Decision
Return for Revision	2024-02-05 20:38
Revised	2024-02-19 11:18
Second Decision	2024-03-06 02:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-06 05:31
Articles in Press	2024-03-06 05:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-22 07:29
Publish the Manuscript Online	2024-03-28 12:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Le-Tian Zhang, Ying Zhang, Bi-Yang Cao, Chen-Chen Wu and Jing Wang
ORCID	Author(s) ORCID Number Le-Tian Zhang http://orcid.org/0000-0003-3216-9364 Ying Zhang http://orcid.org/0009-0007-7128-7028 Bi-Yang Cao http://orcid.org/0000-0003-2468-4104 Chen-Chen Wu http://orcid.org/0000-0001-5930-4971 Jing Wang http://orcid.org/0000-0001-8582-0267
Funding Agency and Grant Number
Corresponding Author	Jing Wang, MD, Chief Doctor, Department of Radiation Oncology, First Medical Center of Chinese People's Liberation Army General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. wangjing@301hospital.com.cn
Key Words	Pancreatic cancer; Early-onset; Non-metastatic; Multimodal treatment; Radiotherapy; Overall survival
Core Tip	Young adults are an important subgroup of the pancreatic cancer (PC) patient population. This article describes the comprehensive treatment patterns and survival outcomes for patients with non-metastatic early-onset PC (EOPC) from a high-volume center. We demonstrated that adjuvant therapy significantly improves postoperative survival in patients with limited EOPC. We also found that radiotherapy-based combination therapy achieved favorable outcomes in patients with locally advanced and postoperative recurrence. Our findings support an aggressive multimodal treatment strategy for these unique patients.
Publish Date	2024-03-28 12:17
Citation	Zhang LT, Zhang Y, Cao BY, Wu CC, Wang J. Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer. World J Gastroenterol 2024; 30(12): 1739-1750
URL	https://www.wjgnet.com/1007-9327/full/v30/i12/1739.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i12.1739

Full Article (PDF)	WJG-30-1739-with-cover.pdf
Manuscript File	91961_Auto_Edited-YJP.docx
Answering Reviewers	91961-Answering reviewers.pdf
Audio Core Tip	91961-Audio core tip.mp3
Biostatistics Review Certificate	91961-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	91961-Conflict-of-interest statement.pdf
Copyright License Agreement	91961-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	91961-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	91961-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	91961-Language certificate.pdf
Peer-review Report	91961-Peer-review(s).pdf
Scientific Misconduct Check	91961-Bing-Lin C-2.png
Scientific Editor Work List	91961-Scientific editor work list.pdf